炎症性肠病患者黏附分子-l、D-乳酸、二胺氧化酶的变化及临床意义

被引：15

作者：

钟武装

宋卫兵

杨键

肖丽萍

杨明常

刘岗

谢涣琴

蔡敏捷

乐德

机构：

[1] 广州军区广州总医院干部病房二科

来源：

现代消化及介入诊疗 | 2013年 / 18卷 / 05期

基金：

广东省自然科学基金;

关键词：

炎症性肠病; 细胞间黏附分子-l; D-乳酸; 二胺氧化酶;

D O I：

暂无

中图分类号：

R574 [肠疾病];

学科分类号：

1002 ; 100201 ;

摘要：

目的研究炎症性肠病(Inflammatory Bowel Disease,IBD)患者可溶性血清细胞间黏附分子-l(sICAM-1)、血浆D-乳酸、二胺氧化酶(DAO)、白细胞(WBC)的变化及其临床意义。方法将108例IBD患者和60例健康体检者分为观察组和对照组,对两组分别采用酶联免疫法测定血清sICAM-l,分光光度法检测D-乳酸和DAO水平,常规检查白细胞计数。结果 IBD患者sICAM-1、血浆D-乳酸、DAO、WBC明显高于对照组(P<0.01)。IBD患者sICAM-l与血浆D-乳酸、DAO、WBC水平均显著相关(P<0.01)。治疗前溃疡性结肠炎和克罗恩病两组患者间sICAM-l、DAO、D-乳酸、WBC的水平比较无显著差异性(P>0.05),而治疗后sICAM-l、DAO、D-乳酸水平显著低于治疗前(P<0.01)。结论 sICAM-1,血浆D-乳酸和DAO与病情程度密切相关,sICAM-1可作为IBD患者病情的主要监测指标之一。

引用

页码：273 / 276

页数：4

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