上皮间质转化与循环肿瘤细胞

被引：14

作者：

刘慧颖

殷正丰

机构：

[1] 第二军医大学东方肝胆外科医院分子肿瘤实验室

来源：

肿瘤 | 2013年 / 33卷 / 09期

关键词：

肿瘤转移; 肿瘤循环细胞; 细胞转化,肿瘤; 间质细胞; 上皮细胞; 上皮间质转化; 间质上皮转化;

D O I：

暂无

中图分类号：

R730.2 [肿瘤病理学、病因学];

学科分类号：

摘要：

目前认为,上皮间质转化(epithelial-mesenchymal transition,EMT)程序性激活可使肿瘤细胞获得异常的活动能力,从而诱导循环肿瘤细胞(circulating tumor cells,CTCs)产生并存活,经过血液循环传播后,发生间质上皮转化(mesenchymal-epithelial transition,MET),最终形成继发性转移灶。鉴于EMT是诱导CTCs并促进肿瘤转移的一个关键因素,CTCs-EMT在预后诊断和靶向治疗方面正受到越来越多的关注。本文对有关EMT促进CTCs产生和生存,发生EMT的CTCs又通过MET促进CTCs形成肿瘤转移灶的研究进展进行综述,并讨论了检测CTCs-EMT表型的临床应用问题。

引用

页码：837 / 840

页数：4

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