TGF-β信号传导通路及其生物学功能

被引：212

作者：

刘镕

赵琴平

董惠芬

蒋明森

机构：

[1] 武汉大学基础医学院医学寄生虫学教研室

来源：

中国病原生物学杂志 | 2014年 / 9卷 / 01期

关键词：

TGF-β信号传导通路; 生物学功能; 生殖发育; 胚胎发育; 免疫应答; 综述;

D O I：

10.13350/j.cjpb.140120

中图分类号：

R392 [医学免疫学];

学科分类号：

100108 [医学免疫学];

摘要：

TGF-β信号传导通路是一个包含众多成员的多功能细胞因子大家族,根据配体分子激活的不同的下游特异性通路可以分为TGF-β/Activin/Nodal和BMP/GDF/MIS两个亚家族通路。该信号通路的激活首先是TGF-βs配体分子与受体结合,从而使受体TβRs磷酸化,磷酸化的TβR-I直接作用于底物Smads蛋白,活化的Smads就将配体与受体作用的信号从细胞膜、胞浆传递到细胞核内,再与其他核内因子协同激活或者抑制靶基因的转录。TGF-β信号通路就是通过调节细胞的生长、增殖、分化、迁移和凋亡等过程,在组织与器官的发生和形成(胚胎发育、骨骼等器官形成)、机体的免疫反应等生物过程发挥重要的功能。

引用

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