Mechanisms of TGF-β signaling from cell membrane to the nucleus

被引：5122

作者：

Shi, YG

Massagué, J

机构：

[1] Princeton Univ, Lewis Thomas Lab, Dept Mol Biol, Princeton, NJ 08544 USA

[2] Mem Sloan Kettering Canc Ctr, Howard Hughes Med Inst, Cell Biol Program, New York, NY 10021 USA

来源：

CELL | 2003年 / 113卷 / 06期

关键词：

D O I：

10.1016/S0092-8674(03)00432-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

TGF-β signaling controls a plethora of cellular responses and figures prominently in animal development. Recent cellular, biochemical, and structural studies have revealed significant insight into the mechanisms of the activation of TGF-β receptors through ligand binding, the activation of Smad proteins through phosphorylation, the transcriptional regulation of target gene expression, and the control of Smad protein activity and degradation. This article reviews these latest advances and presents our current understanding on the mechanisms of TGF-β signaling from cell membrane to the nucleus.

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页码：685 / 700

页数：16

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