TNFα/NF-κB信号通路调控非酒精性脂肪性肝病的研究现状

被引：41

作者：

孙婷婷 ^{[1
]}

李京涛 ^{[2
]}

魏海梁 ^{[2
]}

闫曙光 ^{[1
]}

李倩 ^{[1
]}

郭英君 ^{[3
]}

常占杰 ^{[2
]}

机构：

[1] 陕西中医药大学

[2] 陕西中医药大学附属医院

[3] 宁夏回族自治区人民医院

来源：

临床肝胆病杂志 | 2019年 / 35卷 / 09期

关键词：

非酒精性脂肪性肝病; 肿瘤坏死因子α; NF-κB;

D O I：

暂无

中图分类号：

R575.5 [肝代谢障碍];

学科分类号：

100201 [内科学];

摘要：

TNFα可诱导肝脏炎症反应,促进肝细胞变性、坏死。核因子-κB(NF-κB)作为重要的转录调控因子,在非酒精性脂肪性肝病(NAFLD)中起着促进肝脏脂肪变性的重要作用。TNFα/NF-κB信号通路在各种信号刺激的条件下促进了NAFLD的发展。主要讨论了TNFα/NF-κB信号通路在NAFLD中的作用机制,旨在为NAFLD患者提供新的治疗靶点。

引用

页码：2095 / 2098

页数：4

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