依达拉奉与单唾液酸四己糖神经节苷脂钠联用对急性脑梗死的疗效对比

被引：9

作者：

王颖 ^{[1
]}

张宁 ^{[2
]}

刘衍霖 ^{[3
]}

机构：

[1] 山东省胶州市人民医院急诊科

[2] 胶州市人民中医医院内二科

[3] 胶州市人民中医医院保健科

来源：

中国实用医刊 | 2016年 / 43卷 / 12期

关键词：

依达拉奉; 单唾液酸四己糖神经节苷脂钠; 脑梗死,急性;

D O I：

暂无

中图分类号：

R743.3 [急性脑血管疾病（中风）];

学科分类号：

摘要：

目的观察并探讨依达拉奉(Eda)联合单唾液酸四己糖神经节苷脂钠(GM1)治疗急性脑梗死(ACI)的有效性。方法选择2013年10月至2015年5月ACI患者96例,按照随机分组法将96例患者分为两组,观察组和对照组各48例。对照组给予单纯Eda治疗,观察组在对照组基础上联用GM1进行治疗。治疗前后对两组NIHSS量表及BI指数进行评价,并评估两组综合疗效,统计两组不良反应发生情况。结果治疗前,两组患者NIHSS评分及BI得分相比,差异未见统计学意义(P>0.05);治疗后观察组NIHSS得分和BI得分分别为(8.5±3.2)分和(48.3±8.7)分,对照组为(12.4±5.6)分和(42.5±7.4)分,观察组NIHSS评分明显低于对照组,而BI明显高于对照组(P<0.05);观察组有效率为93.8%(45/48),对照组为91.7%(44/48),两组有效率相比,差异未见统计学意义(P>0.05);观察组不良反应发生率为6.3%(3/48),对照组为4.2%(2/48),两组不良反应发生率相比,差异未见统计学意义(P>0.05)。结论 Eda联合GM1治疗能明显改善ACI患者的神经功能和生活质量,且安全有效,值得在临床上进一步推广。

引用

页码：81 / 83

页数：3

共 16 条

[1] 依达拉奉联合长春西汀治疗急性脑梗死疗效观察
菅朝丽
李勇
[J]. 国际医药卫生导报, 2012, (03) : 365 - 368
[2] Simultaneous Administration of Recombinant Tissue Plasminogen Activator and Edaravone in Acute Cerebral Ischemic Stroke Patients[J] . Katsunobu Takenaka,Masayasu Kato,Keita Yamauti,Katsuhiko Hayashi. &nbspJournal of Stroke and Cerebrovascular Diseases . 2014
[3] Edaravone improves functional and structural outcomes in animal models of focal cerebral ischemia: A systematic review[J] . Simiao Wu,Emily Sena,Kieren Egan,Malcolm Macleod,Gillian Mead. &nbspInt J Stroke . 2014 (1)
[4] Edaravone, a free radical scavenger, attenuates cerebral infarction and hemorrhagic infarction in rats with hyperglycemia[J] . Okamura,Tsubokawa,Johshita,Miyazaki,Shiokawa. &nbspNeurological Research . 2014 (1)
[5] Cost-effectiveness Analysis of the Neuroprotective Agent Edaravone for Noncardioembolic Cerebral Infarction
Shinohara, Yukito
Inoue, Sachie
[J]. JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 2013, 22 (05) : 668 - 674
[6] Effects of Edaravone, a Free Radical Scavenger, on Serum Levels of Inflammatory Biomarkers in Acute Brain Infarction[J] . Kenji Isahaya,Koji Yamada,Masato Yamatoku,Kenzo Sakurai,Satoshi Takaishi,Bunta Kato,Toshikazu Hirayama,Yasuhiro Hasegawa. &nbspJournal of Stroke and Cerebrovascular Diseases . 2012 (2)
[7] Administration of edaravone, a free radical scavenger, during t-PA infusion can enhance early recanalization in acute stroke patients — A preliminary study[J] . Kazumi Kimura,Juya Aoki,Yuki Sakamoto,Kazuto Kobayashi,Kenichi Sakai,Takeshi Inoue,Yasuyuki Iguchi,Kensaku Shibazaki. &nbspJournal of the Neurological Sciences . 2011 (1)
[8] Potential of edaravone for neuroprotection in neurologic diseases that do not involve cerebral infarction (Review)
Kikuchi, Kiyoshi
Kawahara, Ko-Ichi
Uchikado, Hisaaki
Miyagi, Naohisa
Kuramoto, Terukazu
Miyagi, Tomoya
Morimoto, Yoko
Ito, Takashi
Tancharoen, Salunya
Miura, Naoki
Takenouchi, Kazunori
Oyama, Yoko
Shrestha, Binita
Matsuda, Fumiyo
Yoshida, Yoshihiro
Arimura, Shinihiro
Mera, Kentaro
Tada, Ko-Ichi
Yoshinaga, Narimasa
Maenosono, Ryuichi
Ohno, Yoshiko
Hashiguchi, Teruto
Maruyama, Ikuro
Shigemori, Minoru
[J]. EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2011, 2 (05) : 771 - 775
[9] 2-Decenoic Acid Ethyl Ester, a Compound That Elicits Neurotrophin-like Intracellular Signals, Facilitating Functional Recovery from Cerebral Infarction in Mice. Tanaka Yoshitaka,Fukumitsu Hidefumi,Soumiya Hitomi,Yoshimura Shinichi,Iwama Toru,Furukawa Shoei. International journal of molecular sciences . 2012
[10] Edaravone,a free radical scavenger,attenuates cerebral infarction and hemorrhagic infarction in rats with hyperglycemia. Okamura K,Tsubokawa T,Johshita H,et al. Neurological Research . 2014

← 1 2 →