原发性胆汁性肝硬化的临床诊治

被引:3
作者
汪嘉莉
姚云清
机构
[1] 重庆医科大学附属第一医院感染科
关键词
原发性胆汁性肝硬化; 临床表现; 诊断; 治疗;
D O I
暂无
中图分类号
R575.2 [肝硬变];
学科分类号
100201 [内科学];
摘要
原发性胆汁性肝硬化(PBC)是一种原因不明的慢性进展性胆汁淤积性肝病。临床上可以表现为无临床症状,也可以表现为肝硬化。诊断PBC依赖于反映胆汁淤积的生化指标、抗线粒体抗体阳性和非化脓性胆管炎的组织学改变。熊去氧胆酸被认为是能改善PBC预后的有效药物,然而,仍有1/3的患者用熊去氧胆酸后未达到满意效果而做肝移植治疗。因此,需要早期诊断PBC和发明新的药物来解决这一问题。
引用
收藏
页码:1515 / 1517
页数:3
相关论文
共 15 条
[1]
原发性胆汁性肝硬化的研究进展 [J].
贾继东 ;
段维佳 .
中华肝脏病杂志, 2011, (05)
[2]
Primary biliary cirrhosis:What do autoantibodies tell us?[J] Chao-Jun Hu;Feng-Chun Zhang;Yong-Zhe Li;Xuan Zhang;Department of Rheumatology and Clinical Immunology;Peking Union Medical College Hospital;Peking Union Medical College and Chinese Academy of Medical Sciences;Beijing 100032;China World Journal of Gastroenterology 2010,
[3]
自身免疫性肝病重叠综合征的临床诊治进展 [J].
林菊生 ;
余金玲 .
中华肝脏病杂志, 2010, (05)
[4]
Primary biliary cirrhosis[J] Douglas L. Nguyen;Brian D. Juran;Konstantinos N. Lazaridis Best Practice & Research Clinical Gastroenterology 2010,
[5]
The independent effects of fatigue and UDCA therapy on mortality in primary biliary cirrhosis: Results of a 9<ce:hsp sp="0.25"/>year follow-up[J] David E. Jones;Ahmad Al-Rifai;James Frith;Imran Patanwala;Julia L. Newton Journal of Hepatology 2010,
[6]
Demographic; lifestyle; medical and familial factors associated with primary biliary cirrhosis[J] Christophe Corpechot;Yves Chrétien;Olivier Chazouillères;Raoul Poupon Journal of Hepatology 2010,
[7]
Methotrexate in Patients with Primary Biliary Cirrhosis Who Respond Incompletely to Treatment With Ursodeoxycholic Acid[J] Marshall M. Kaplan;Alan Bonder;Robin Ruthazer;Peter A. L. Bonis Digestive Diseases and Sciences 2010,
[8]
Treatment of Primary Biliary Cirrhosis: A new challenge?[J] Koji Fukushima;Yoshiyuki Ueno;Tooru Shimosegawa Hepatology Research 2010,
[9]
Epidemiology and natural history of primary biliary cirrhosis in a Canadian health region: A population‐based study[J] Robert P. Myers;Abdel Aziz M. Shaheen;Andrew Fong;Kelly W. Burak;Alex Wan;Mark G. Swain;Robert J. Hilsden;Lloyd Sutherland;Hude Quan Hepatology 2009,
[10]
EASL Clinical Practice Guidelines: Management of cholestatic liver diseases[J] European Association for the Study of the Liver Journal of Hepatology 2009,