H5N1亚型禽流感病毒的流行与致病性

被引：21

作者：

孙洪磊

刘金华

机构：

[1] 中国农业大学动物医学院

来源：

生命科学 | 2015年 / 27卷 / 05期

基金：

国家杰出青年科学基金;

关键词：

H5N1亚型禽流感病毒; 流行性; 传播性; 致病性;

D O I：

10.13376/j.cbls/2015069

中图分类号：

R373.1 [呼吸道传染性病毒]; S852.65 [家畜病毒学];

学科分类号：

090507 [智慧养殖与动物生产学]; 100123 [人体微生态学];

摘要：

H5N1禽流感病毒在禽类中广泛流行,对家禽养殖业造成严重经济损失。1997年香港地区首次出现人感染H5N1禽流感病例,2003年之后多个国家相继出现H5N1禽流感病毒感染人事件,目前已有16个国家650人感染发病,患者死亡率高达60%以上。随着H5N1禽流感病毒的持续流行与进化,该病毒仍然对公共卫生具有严重威胁。综述了H5N1禽流感病毒的进化特点、流行情况以及致病性。

引用

页码：525 / 530

页数：6

共 9 条

[1]

H5N1 avian influenza in China [J].

Chen HuaLan .

SCIENCE IN CHINA SERIES C-LIFE SCIENCES, 2009, 52 (05) :419-427

[2]

Bat-derived influenza-like viruses H17N10 and H18N11 [J].

Wu, Ying ;

Wu, Yan ;

Tefsen, Boris ;

Shi, Yi ;

Gao, George F. .

TRENDS IN MICROBIOLOGY, 2014, 22 (04) :183-191

[3]

Characterization of three H5N5 and one H5N8 highly pathogenic avian influenza viruses in China [J].

Zhao, Kunkun ;

Gu, Min ;

Zhong, Lei ;

Duan, Zhiqiang ;

Zhang, Yan ;

Zhu, Yanmei ;

Zhao, Guo ;

Zhao, Mingjun ;

Chen, Zhaoyang ;

Hu, Shunlin ;

Liu, Wenbo ;

Liu, Xiaowen ;

Peng, Daxin ;

Liu, Xiufan .

VETERINARY MICROBIOLOGY, 2013, 163 (3-4) :351-357

[4]

Airborne Transmission of Influenza A/H5N1 Virus Between Ferrets [J].

Herfst, Sander ;

Schrauwen, Eefje J. A. ;

Linster, Martin ;

Chutinimitkul, Salin ;

de Wit, Emmie ;

Munster, Vincent J. ;

Sorrell, Erin M. ;

Bestebroer, Theo M. ;

Burke, David F. ;

Smith, Derek J. ;

Rimmelzwaan, Guus F. ;

Osterhaus, Albert D. M. E. ;

Fouchier, Ron A. M. .

SCIENCE, 2012, 336 (6088) :1534-1541

[5]

Seasonal and Pandemic Human Influenza Viruses Attach Better to Human Upper Respiratory Tract Epithelium than Avian Influenza Viruses [J].

van Riel, Debby ;

den Bakker, Michael A. ;

Leijten, Lonneke M. E. ;

Chutinimitkul, Salin ;

Munster, Vincent J. ;

de Wit, Emmie ;

Rimmelzwaan, Guus F. ;

Fouchier, Ron A. M. ;

Osterhaus, Albert D. M. E. ;

Kuiken, Thijs .

AMERICAN JOURNAL OF PATHOLOGY, 2010, 176 (04) :1614-1618

[6]

Influenza A/H5N1 virus infection in humans in Cambodia [J].

Buchy, Philippe ;

Mardy, Sek ;

Vong, Sirenda ;

Toyoda, Tetsuya ;

Aubin, Jean-Thierry ;

Miller, Megge ;

Touch, Sok ;

Sovann, Ly ;

Dufourcq, Jean-Baptiste ;

Richner, Beat ;

Van Tu, Phan ;

Tien, Nguyen Thi Kim ;

Lim, Wilina ;

Peiris, J. S. Malik ;

Van der Werf, Sylvie .

JOURNAL OF CLINICAL VIROLOGY, 2007, 39 (03) :164-168

[7]

H5N1 infection of the respiratory tract and beyond: a molecular pathology study [J].

Gu, Jiang ;

Xie, Zhigang ;

Gao, Zhancheng ;

Liu, Jinhua ;

Korteweg, Christine ;

Ye, Juxiang ;

Lau, Lok Ting ;

Lu, Jie ;

Gao, Zifen ;

Zhang, Bo ;

McNutt, Michael A. ;

Lu, Min ;

Anderson, Virginia M. ;

Gong, Encong ;

Yu, Albert Cheung Hoi ;

Lipkin, W. Ian .

LANCET, 2007, 370 (9593) :1137-1145

[8]

Human and avian influenza viruses target different cells in the lower respiratory tract of humans and other mammals [J].

van Riel, Debby ;

Munster, Vincent J. ;

de Wit, Emmie ;

Rimmelzwaan, Guus F. ;

Fouchier, Ron A. M. ;

Osterhaus, Albert D. M. E. ;

Kuiken, Thijs .

AMERICAN JOURNAL OF PATHOLOGY, 2007, 171 (04) :1215-1223

[9]

Induction of proinflammatory cytokines in human macrophages by influenza A (H5N1) viruses: a mechanism for the unusual severity of human disease? [J].

Cheung, CY ;

Poon, LLM ;

Lau, AS ;

Luk, W ;

Lau, YL ;

Shortridge, KF ;

Gordon, S ;

Guan, Y ;

Peiris, JSM .

LANCET, 2002, 360 (9348) :1831-1837

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