Wnt/β-catenin信号通路及其对骨髓间充质干细胞多向分化调节研究进展

被引：20

作者：

李云矗 ^{[1
]}

徐刚 ^{[2
]}

徐成福 ^{[2
]}

机构：

[1] 牡丹江医学院

[2] 牡丹江医学院红旗医院骨二科

来源：

牡丹江医学院学报 | 2016年 / 37卷 / 01期

关键词：

经典Wnt信号通路; 骨髓间充质干细胞; 分化;

D O I：

10.13799/j.cnki.mdjyxyxb.2016.01.037

中图分类号：

R329.2 [人体细胞学];

学科分类号：

100107 [人体解剖与组织胚胎学（人体解剖学、组织与胚胎学）];

摘要：

Wnt/β-catenin信号通路(经典Wnt信号通路)作为调节细胞生长和分化的重要信号途径一直是医学研究的重点。近年研究表明,在骨髓间充质干细胞向成骨细胞、脂肪细胞和软骨细胞定向分化的过程中经典Wnt信号传导通路发挥着重要的调控作用,其调控机制已经成为骨组织工程学研究的热点,同时也为骨代谢疾病的治疗提供了新的思路和手段。文章集中近几年经典Wnt信号传导通路的研究成果,从经典Wnt信号通路的组成、信号传导途径、对骨髓间充质干细胞多向分化的调控等方面进行综述。

引用

页码：99 / 102

页数：4

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