Agilent快速高分离液相色谱(RRLC)/6410串联四极质谱测定二甲双胍的血药浓度

被引：3

作者：

梁峰

王颖

李平

机构：

[1] 安捷伦科技有限公司(北京)

来源：

分析测试学报 | 2007年 / S1期

关键词：

RRLC/6410; QQQ; Di-methy/di-carba midine; Plasma;

D O I：

暂无

中图分类号：

R96 [药理学];

学科分类号：

100602 ; 100706 ;

摘要：

A traditional HPLC and a rapid resolution (RRLC) method coupled with triple Q MS was established to determine the di-methyl di-carbamidine in plasma.Result showed that RRLC-MS/MS obtained a low LOD at 0.14 pg on column compared to 0.83 pg by conventional HPLC-MS/MS and thus increased sensitivity by 6 times,shortened analytical time by 3 times while maintaining a satisfactory testing result using Agilent LCQQQ.

引用

页码：96 / 97

页数：2