网膜素:一个新的脂肪因子

被引：18

作者：

龚磊

白波

陈京

机构：

[1] 济宁医学院神经生物学研究所

来源：

生理科学进展 | 2011年 / 42卷 / 05期

关键词：

网膜素; 脂肪因子; 肥胖; 胰岛素抵抗;

D O I：

暂无

中图分类号：

Q54 [脂类];

学科分类号：

070307 [化学生物学];

摘要：

脂肪因子(adipokines)是由脂肪组织分泌的细胞因子家族,广泛参与调节和维持糖、脂代谢平衡及血管内皮功能。网膜素是新发现的一类由网膜脂肪组织分泌的脂肪因子,参与调控机体的内分泌、能量代谢及炎症的发生发展。研究发现,网膜素可以促进脂肪细胞对胰岛素介导的葡萄糖的摄取作用,并促进胰岛素受体后信号通路中的Akt磷酸化;其次,网膜素具有抗炎作用,尤其在血管内皮细胞炎症过程中的抗炎机理已被首次证实;另外,网膜素对血管还有舒张作用,尤其在冠状动脉粥样硬化中发挥保护性作用。因此,网膜素可能是联系炎症和动脉粥样硬化间的重要分子,可能成为潜在的标志性分子或药物作用靶点。本文拟就网膜素的新近研究进展予以综述。

引用

收藏

页码：390 / 393

页数：4

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