糖尿病研究进展

被引：47

作者：

郑丽 ^{[1
]}

徐涛 ^{[1
,2
]}

机构：

[1] 中国科学院生物物理研究所

[2] 华中科技大学生命科学与技术学院

来源：

生命科学 | 2012年 / 24卷 / 07期

基金：

中国科学院知识创新工程重大项目;

关键词：

糖尿病; 代谢性疾病; 并发症; 胰岛素响应性; 胰岛功能;

D O I：

10.13376/j.cbls/2012.07.003

中图分类号：

R587.1 [糖尿病];

学科分类号：

摘要：

糖尿病是一种以失控的高血糖为主要表现,多种并发症为主要损害的一种代谢性疾病,已严重影响人们的健康生活。从胰岛素靶器官的响应性、胰岛功能、胃肠分泌因子的调节和基因水平等方面对糖尿病的研究进展进行综述。

引用

页码：606 / 610

页数：5

共 9 条

[1]

Changes in Glucose Homeostasis after Roux-en-Y Gastric Bypass Surgery for Obesity at Day Three, Two Months, and One Year after Surgery: Role of Gut Peptides[J] . The Journal of Clinical Endocrinology & Metabolism . 2011 (7)

[2] Clinical and molecular genetics of neonatal diabetes due to mutations in the insulin gene [J].

Stoy, Julie ;

Steiner, Donald F. ;

Park, Soo-Young ;

Ye, Honggang ;

Philipson, Louis H. ;

Bell, Graeme I. .

REVIEWS IN ENDOCRINE & METABOLIC DISORDERS, 2010, 11 (03) :205-215

[3] Mechanisms facilitating weight loss and resolution of type 2 diabetes following bariatric surgery [J].

Karra, Efthimia ;

Yousseif, Ahmed ;

Batterham, Rachel L. .

TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2010, 21 (06) :337-344

[4] Rapid activation of Akt2 is sufficient to stimulate GLUT4 translocation in 3T3-L1 adipocytes [J].

Ng, Yvonne ;

Ramm, Georg ;

Lopez, Jamie A. ;

James, David E. .

CELL METABOLISM, 2008, 7 (04) :348-356

[5] Dissecting multiple steps of GLUT4 trafficking and identifying the sites of insulin action [J].

Bai, Li ;

Wang, Yan ;

Fan, Junmei ;

Chen, Yu ;

Ji, Wei ;

Qu, Anlian ;

Xu, Pingyong ;

James, David E. ;

Xu, Tao .

CELL METABOLISM, 2007, 5 (01) :47-57

[6]

Permanent Neonatal Diabetes Caused by Dominant, Recessive, or Compound Heterozygous SUR1 Mutations with Opposite Functional Effects[J] . Sian Ellard,Sarah E. Flanagan,Christophe A. Girard,Ann-Marie Patch,Lorna W. Harries,Andrew Parrish,Emma L. Edghill,Deborah J.G. Mackay,Peter Proks,Kenju Shimomura,Holger Haberland,Dennis J. Carson,Julian P.H. Shield,Andrew T. Hattersley,Frances M. Ashcroft.The American Journal of Human Genetics . 2007 (2)

[7] Insulin granule dynamics in pancreatic beta cells [J].

Rorsman, P ;

Renström, E .

DIABETOLOGIA, 2003, 46 (08) :1029-1045

[8]

Assays for Insulin, Proinsulin(S) and C-Peptide[J] . P M Clark.Annals of Clinical Biochemistry . 1999 (5)

[9]

Function and dysfunction of aPKC isoforms for glucose transport in insulin-sensitive and insulin-resistant states .2 Farese RV. American Journal of Physiology - Endocrinology and Metabolism . 2002

← 1 →