MicroRNA与乳腺癌侵袭转移的关系

被引：5

作者：

张众 ^{[1
]}

李连宏 ^{[1
]}

Xiao Gray Guishan ^{[2
]}

石宇 ^{[3
]}

谢丰培 ^{[1
]}

机构：

[1] 大连医科大学病理学教研室

[2] Creighton University Medical Center，USA

[3] Thomas Jefferson University

来源：

临床与实验病理学杂志 | 2012年 / 28卷 / 07期

关键词：

乳腺肿瘤; microRNA; 癌侵袭; 转移;

D O I：

10.13315/j.cnki.cjcep.2012.07.008

中图分类号：

R737.9 [乳腺肿瘤];

学科分类号：

摘要：

文献报道显示乳腺原位癌与侵袭癌相关microRNA种类既有相同者,也有相异者。乳腺癌相关microRNA对癌变和(或)转移的调控能力有的兼具二者,有的仅具其一。microRNA对乳腺癌侵袭、转移的作用包括调控癌细胞迁徙、侵袭与生存能力,改变微环境与促进血管生成及启动瘤细胞上皮——间质转变。乳腺癌干细胞在microRNA调控下不仅促进乳腺癌发生,也与癌侵袭转移的发生、发展密切相关。

引用

页码：713 / 716

页数：4

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