慢性阻塞性肺疾病患者凝血功能异常与氧化应激的关系

被引：13

作者：

黄瑾 ^{[1
]}

刘晓菊 ^{[1
]}

包海荣 ^{[1
]}

张艺 ^{[1
]}

谭恩丽 ^{[1
]}

廖剑敏 ^{[1
]}

机构：

[1] 兰州大学第一医院老年呼吸科

来源：

中华内科杂志 | 2011年 / 08期

关键词：

肺疾病; 慢性阻塞性; 凝血致活酶; 氧化性应激;

D O I：

暂无

中图分类号：

R563.9 [其他];

学科分类号：

1002 ; 100201 ;

摘要：

目的探讨慢性阻塞性肺疾病（COPD）急性加重（AECOPD）患者凝血功能异常与氧化应激的关系。方法选28例AECOPD患者和30例健康对照者,检测其血浆中组织因子（TF）、组织因子途径抑制剂（TFPI）活性、总抗氧化能力（TAC）、丙二醛（MDA）、谷胱甘肽过氧化物酶（GSH-PX）活性及肺功能,并行动脉血气分析。结果（1）与治疗前比较,AECOPD患者治疗后血浆TF、TFPI、TF/TFPI水平均明显下降（P<0.01）,但仍高于健康对照者（P<0.01）。（2）与治疗前比较,AECOPD患者治疗后血浆TAC、GSH-PX水平虽升高,但仍低于健康对照者;治疗后血浆MDA水平下降,但仍高于健康对照者（P<0.05）。（3）相关分析:AECOPD患者治疗前TF/TFPI与血浆TAC、GSH-PX、PaO2呈负相关（r分别为-0.518、-0.454、-0.511;P<0.01,P<0.05,P<0.01）,与中性粒细胞百分比呈正相关（r=0.379,P<0.05）;而AECOPD患者治疗后TF/TFPI与血浆TAC、第1秒用力呼气容积占预计值百分比呈负相关（r分别为-0.420、-0.480;P值均小于0.05）,与血浆MDA呈正相关（r=0.451,P<0.05）。结论 AECOPD患者存在凝血/抗凝失衡及氧化/抗氧化失衡,凝血/抗凝失衡与氧化/抗氧化失衡之间存在显著相关性。

引用

共 22 条

[11]

Coagulation factors as biological risk markers of endothelial dysfunction.Association with the thrombotic episodes of chronic hemodialysis patients. Sioulis A,Malindretos P,Makedou A,et al. Hippokratia . 2009

[12]

Antioxidant enzymes and melatonin levels in patients with bronchial asthma and chronic obstructive pulmonary disease during stable and exacerbation periods. Gumral N,Naziroglu M,Ongel K,et al. Cell Biochemistry and Function . 2009

[13]

Chronic viral hepatitis C,oxidative stress and the coagulation/fibrinolysis system in haemodialysis patients. Pawlak K,Zolbach K,Borawski J,et al. Thrombosis Research . 2008

[14]

Chronic viral hepatitis C, oxidative stress and the coagulation/fibrinolysis system in haemodialysis patients[J] . Krystyna Pawlak,Krzysztof Zolbach,Jacek Borawski,Michal Mysliwiec,Oksana Kovalchuk,Lech Chyczewski,Dariusz Pawlak. &nbspThrombosis Research . 2008 (1)

[15]

Prevalence of Pulmonary Embolism in Acute Exacerbations of COPD[J] . Jacques Rizkallah,S.F. Paul Man,Don D. Sin. &nbspChest . 2009 (3)

[16]

Cytokine and cytokine-like inflammation markers,endothelial dysfunction,and imbalanced coagulation in development of diabetes and its complications. Goldberg RB. The Journal of Clinical Endocrinology . 2009

[17]

Oxidative stress in patients with COPD and pulmonary hypertension. P Joppa,D Petrasova,B Stancak,Z Dorkova,R Tkacova. Wiener Klinische Wochenschrift . 2007

[18]

CD40 ligand enhances monocyte tissue factor expression and thrombin generation via oxidative stress in patients with hypercholesterolemia. Sanguigni,V.,Ferro,D.,Pignatelli,P. Journal of the American College of Cardiology . 2005

[19]

Endothelial-co-agulative activation during chronic obstructive pulmonarydisease exacerbations. Polosa R,Cacciola RR,Prosperini Get al. Haematologica . 2008

[20] CD40 ligand enhances monocyte tissue factor expression and thrombin generation via oxidative stress in patients with hypercholesterolemia [J].

Sanguigni, V ;

Ferro, D ;

Pignatelli, P ;

Del Ben, M ;

Nadia, T ;

Saliola, M ;

Sorge, R ;

Violi, F .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2005, 45 (01) :35-42

← 1 2 3 →