基于“肠-关节”轴探讨肠道微生物对膝骨关节炎的影响

被引：14

作者：

谭春霞 ^{[1
]}

杨娜娜 ^{[1
]}

齐翎羽 ^{[1
]}

林璐璐 ^{[1
]}

李月婕 ^{[1
]}

杨静雯 ^{[1
,2
]}

刘存志 ^{[1
,2
]}

石广霞 ^{[1
,2
]}

机构：

[1] 北京中医药大学针灸推拿学院

[2] 北京中医药大学国际针灸创新研究院

来源：

南京中医药大学学报 | 2022年 / 38卷 / 05期

基金：

国家重点研发计划;

关键词：

“肠-关节”轴; 肠道微生物; 膝骨关节炎; 骨关节炎; 低度炎症;

D O I：

10.14148/j.issn.1672-0482.2022.0461

中图分类号：

R274.9 [现代医学骨伤科疾病];

学科分类号：

100210 [外科学];

摘要：

近年来，随着微生物组学的飞速发展，现代医学提出了“肠-关节”轴概念。“肠-关节”轴在肠道微生物和关节疾病中扮演着重要角色。肠道微生物的紊乱导致慢性系统性低度炎症，进而加重骨关节炎的病理进程。调节肠道微生物的平衡可能会通过抑制胃肠或膝关节局部的免疫炎症反应来改善膝骨关节炎的症状。笔者基于“肠-关节”轴探讨肠道微生物对膝骨关节炎的潜在影响，以及肠道微生物治疗膝骨关节炎的可行性。

引用

页码：461 / 466

页数：6

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