他汀类药物对急性缺血性脑卒中患者外周血内皮祖细胞的影响

被引：10

作者：

陈雅玲

董强

机构：

[1] 复旦大学附属华山医院神经内科

来源：

中国临床神经科学 | 2009年 / 17卷 / 02期

关键词：

急性缺血性脑卒中; 他汀类药物; 内皮祖细胞;

D O I：

暂无

中图分类号：

R743.3 [急性脑血管疾病（中风）];

学科分类号：

摘要：

目的:观察他汀类药物对急性缺血性脑卒中（AIS）患者外周血内皮祖细胞（EPC）数量及迁移能力的影响。方法: 15例发病1周内的AIS患者,给予阿托伐他汀20 mg·d-1,治疗4周,用药前及用药后每周分别检测外周血EPC数量及迁移能力;9名健康对照者于入组前及第2、4周随访。结果:阿托伐他汀治疗第2周开始EPC数量逐渐增多,且第3和第4周增多较为显著（P<0.05）;EPC的迁移能力在治疗第2和第3周显著提高（P<0.05）,而第4周则有下降的趋势。EPC数量及迁移能力的变化与低密度脂蛋白的下降无显著相关性。结论:他汀类药物可能提高AIS患者外周血EPC的数量及迁移能力。

引用

页码：128 / 133

页数：6

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