树突状细胞与调节性T细胞相互作用研究进展

被引：16

作者：

黄立锋

姚咏明

盛志勇

机构：

[1] 解放军总医院第一附属医院全军烧伤研究所基础部

来源：

中国病理生理杂志 | 2008年 / 03期

基金：

国家杰出青年科学基金;

关键词：

树突细胞; 调节性T细胞; 免疫调节;

D O I：

暂无

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Dendritic cells(DCs),representing a heterogenous population of professional antigen-presenting cells,are the initiators and modulators of the immune responses.Studies indicate that regulatory T cells contribute to immune nullipotency and immune suppression via cell-cell contact or cytokine secretion.These two kinds of cells may be valuable tools for modulating immunity in the setting of autoimmunity,cancer,chronic viral infections and graft rejection,etc.Here we discuss the current knowledge on the functions of regulatory T cells and denditic cells-based immunoregulation and the applications.

引用

页码：610 / 616

页数：7

共 8 条

[1] 抗原致敏DC与CIK共培养体外抗肾癌效应的研究 [J].

湛海伦 ;

高新 ;

邱剑光 ;

蔡育彬 ;

司徒杰 ;

温星桥 .

中国病理生理杂志, 2006, (10) :1993-1996

[2] 肿瘤抗原联合CD40L致敏树突状细胞诱导CTLs杀伤K562细胞的实验研究 [J].

林东军 ;

方志刚 ;

付咏梅 ;

李旭东 ;

黄仁魏 .

中国病理生理杂志, 2006, (09) :1751-1755

[3] 树突状细胞的研究热点及其与疾病的防治 [J].

曹雪涛 .

中华医学杂志, 1999, (03) :3-5

[4]

The interactions of dendritic cells with antigen-specific, regulatory T cells that suppress autoimmunity[J] . Kristin V. Tarbell,Sayuri Yamazaki,Ralph M. Steinman.Seminars in Immunology . 2006 (2)

[5] Role of regulatory T cells in human diseases [J].

Chatila, TA .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2005, 116 (05) :949-959

[6] Exposure to the electrofusion process can increase the immunogenicity of human cells [J].

Hock, BD ;

Roberts, G ;

McKenzie, JL ;

Gokhale, P ;

Salm, N ;

McLellan, AD ;

Patton, NW ;

Roake, JA .

CANCER IMMUNOLOGY IMMUNOTHERAPY, 2005, 54 (09) :880-890

[7]

Plasmacytoid dendritic cells induce CD8+regulatory T cells in human ovarian carcinoma. Wei S,Kryczek I,Zou L, et al. Cancer Research . 2005

[8]

Activation of human NK cells by plasmacytoid dendritic cells and its modulation by CD4+T helper cells and CD4+CD25hi T regulatory cells. Romagnani C,Della Chiesa M,Thiel A et al. European Journal of Immunology . 2005

← 1 →