喹诺酮信号系统研究进展

被引：4

作者：

郑红达 ^{[1
,2
]}

周丽曼 ^{[1
,2
]}

唐艺丹 ^{[1
,2
]}

于文功 ^{[1
,2
]}

宫倩红 ^{[1
,2
]}

机构：

[1] 中国海洋大学医药学院

[2] 海洋药物教育部重点实验室

来源：

现代生物医学进展 | 2014年 / 14卷 / 11期

关键词：

喹诺酮信号系统; 群体感应; 铜绿假单胞菌;

D O I：

10.13241/j.cnki.pmb.2014.11.043

中图分类号：

R378 [病原细菌];

学科分类号：

100103 ; 100705 ;

摘要：

喹诺酮信号系统是铜绿假单胞菌群体感应调控网络中一个重要组成部分,对于绿脓菌素和弹性蛋白酶等毒力因子的表达及细菌生物被膜形成和细菌运动具有重要的调控作用,因此与临床细菌感染密切相关。3,4-二羟基-2-庚基-喹诺酮(Pseudomonas quinolone signal,PQS)及2-庚基-4喹诺酮(4-hydroxy-2-heptylquinoline,HHQ)是pqs调控系统中重要的信号分子。PQS对于细菌在压力下群体密度及细菌物质运输具有调控作用,从而增强细菌对于环境的适应能力。同时PQS等分子在一定程度上抑制了人体的免疫系统,帮助细菌在宿主体内生存。HHQ在其他革兰氏阴性细菌及革兰氏阳性细菌中也有合成并发挥调控作用,所以喹诺酮信号分子不仅是种内也是种间交流媒介。将喹诺酮系统作为靶点降低细菌的信号交流是抑制细菌感染的一个新思路。本文对喹诺酮信号系统进行概述。

引用

页码：2170 / 2172+2192 +2192

页数：4

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