Wnt信号通路:调控机理和生物学意义

被引：198

作者：

尹定子

宋海云

机构：

[1] 中国科学院系统生物学重点实验室

来源：

中国细胞生物学学报 | 2011年 / 33卷 / 02期

关键词：

Wnt; beta-Catenin; TCF; 发育; 疾病;

D O I：

暂无

中图分类号：

Q257 [细胞内的信息传递];

学科分类号：

071003 [生理学];

摘要：

Wnt信号通路作为一种在进化中高度保守的信号通路,在生长、发育、代谢和干细胞维持等多种生物学过程中发挥重要作用。而Wnt通路的失控与癌症、肥胖和糖尿病等疾病的发生有密切联系。经典Wnt通路的调控过程,主要围绕beta-Catenin和TCF这两个关键调节因子进行,从而在转录水平上影响着大量与生长和代谢相关的靶基因的表达。本文将综合介绍近年来针对经典Wnt通路调控机理的研究进展,以及Wnt通路与疾病发生的关系。

引用

收藏

页码：103 / 111

页数：9

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