Wnt-signalling and the Metabolic Syndrome

被引：113

作者：

Schinner, S. ^{[1
]}

机构：

[1] Univ Hosp Dusseldorf, Dept Endocrinol Diabet & Rheumatol, D-40225 Dusseldorf, Germany

来源：

HORMONE AND METABOLIC RESEARCH | 2009年 / 41卷 / 02期

关键词：

beta-cells; diabetes mellitus type 2; insulin secretion; Wnt; BETA-CELL PROLIFERATION; TCF7L2; GENE; INSULIN-SECRETION; ADIPOSE-TISSUE; ADRENOCORTICAL-CELLS; TRANSCRIPTION; POLYMORPHISMS; ADIPOGENESIS; ASSOCIATION; POPULATION;

D O I：

10.1055/s-0028-1119408

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

The Wnt-signalling pathway plays a well-established role in embryogenesis and tumourigenesis. However, recent data puts Wnt-signalling in the context of metabolic disease. In vitro and in vivo data characterised the role of Wnt-signalling molecules in the regulation of adipocyte differentiation (adipogenesis). Furthermore, Writs play a pivotal role in regulating pancreatic beta-cell function and mass. In addition, studies found polymorphisms within the gene encoding TCF7L2, a Wnt-regulated transcription factor, to contribute an increased risk to develop type 2 diabetes mellitus in humans. This review will summarise recent aspects of Wnt-signilling in these pathophysiologic events and discuss the contributions of dysregulation in Wnt-signalling to features of the metabolic syndrome.

引用

页码：159 / 163

页数：5

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