抗抑郁药物的研究进展

被引：63

作者：

李玥

贺敏

张磊阳

裘福荣

陈文文

吴雨

杨蒋伟

蒋健

机构：

[1] 上海中医药大学附属曙光医院临床药理科

来源：

临床药物治疗杂志 | 2017年 / 15卷 / 01期

关键词：

抑郁症; 抗抑郁药物; 单胺类神经递质; 速效抗抑郁药物;

D O I：

暂无

中图分类号：

R749.4 [情感性精神病];

学科分类号：

100204 [神经病学];

摘要：

目的:对临床上使用的及临床试验中的抗抑郁药物进行分析和总结,拟为今后新型抗抑郁药物的研发提供参考。方法:通过查阅近年的文献,将抗抑郁药物按照机制进行归纳和整理。结果:从第一代的三环类、单胺氧化酶抑制剂类抗抑郁药物,到第二代的基于单胺类神经递质及相应受体所研发的药物,之前的研发集中在调节单胺类神经递质的摄取和释放方面。而随着氯胺酮等快速起效的抗抑郁药物的发现,新的靶点,比如谷氨酸神经递质及相关通路成为研究的热点。结论:抗抑郁药物的发展仍会遵循着单胺类的策略,但是靶向谷氨酸神经递质系统的药物及联合用药是新的发展趋势。

引用

页码：8 / 13

页数：6

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