帕金森病与神经免疫炎症研究的新进展

被引:16
作者
高靓
张玉虎
王丽娟
机构
[1] 广东省人民医院神经内科
基金
广东省科技计划;
关键词
多巴胺能神经元; IgG; PD; 小胶质细胞; 外周血; 自身抗体; 细胞因子; 小神经胶质; 帕金森病; 黑质纹状体系统;
D O I
暂无
中图分类号
R742.5 [震颤麻痹综合征];
学科分类号
1002 ;
摘要
<正>既往认为帕金森病(PD)的病因是遗传因素、环境因素、衰老、氧化应激、线粒体功能障碍等多种因素协同作用的结果。近来神经免疫炎症机制在PD中的作用受到普遍关注。许多临床研究[1,2]发现PD患者血清、CSF的炎性细胞因子水平显著增高,炎症活化T淋巴细胞亚型增多,并且B淋巴细胞产生抗体增多。在PD患者正电子发射计算机断层扫描的研究中,应用示踪剂[11C](R)-PK11195标记激活的小胶质细
引用
收藏
页码:234 / 236
页数:3
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