基于“骨肉不相亲”理论探讨骨骼肌源性外泌体在老年性骨质疏松中的作用

被引：20

作者：

沈耿杨 ^{[1
,2
]}

黄璇 ^{[2
,3
]}

尚奇 ^{[2
,3
]}

江晓兵 ^{[1
,2
]}

余翔 ^{[1
,2
]}

张志达 ^{[2
,3
]}

招文华 ^{[2
,3
]}

汤凯 ^{[2
,3
]}

梁德 ^{[1
,2
]}

任辉 ^{[1
,2
]}

机构：

[1] 广州中医药大学第一附属医院

[2] 广州中医药大学岭南医学研究中心

[3] 广州中医药大学

来源：

中国骨质疏松杂志 | 2020年 / 26卷 / 11期

基金：

广东省自然科学基金; 广东省高等学校珠江学者岗位计划资助项目;

关键词：

中医中药; 老年性骨质疏松; 骨痿; 骨肉不相亲; 骨骼肌源性外泌体; 骨稳态;

D O I：

暂无

中图分类号：

R580 [];

学科分类号：

摘要：

中医学"骨肉不相亲"理论高度概括了老年性骨质疏松(senile osteoporosis,SOP)骨骼和骨骼肌的内在失衡状态,外泌体作为一种细胞囊泡可携带多种生物活性分子在"骨-肌交联"中发挥关键的调控作用。本文基于"骨肉不相亲"理论探讨骨骼肌源性外泌体在SOP中的作用,对挖掘中医药防治SOP的新靶点及丰富"骨肉不相亲"理论的现代科学内涵具有重要意义。中医学调理脾肾、强肌健骨是治疗SOP"骨肉不相亲"的关键,为防治SOP提供了新的思路。

引用

页码：1700 / 1703

页数：4

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