强制性跑台训练对大鼠海马NR1和NR2BmRNA表达及学习记忆能力的影响

被引：11

作者：

黄涛 ^{[1
]}

夏志 ^{[1
]}

徐波 ^{[2
]}

机构：

[1] 井冈山大学体育学院

[2] 华东师范大学体育与健康学院

来源：

天津体育学院学报 | 2009年 / 24卷 / 04期

关键词：

运动; NR1; NR2B; 学习记忆;

D O I：

10.13297/j.cnki.issn1005-0000.2009.04.001

中图分类号：

R87 [运动医学];

学科分类号：

100911 [运动医学];

摘要：

目的:研究8周强制性跑台运动训练对大鼠海马NR1和NR2BmRNA表达及学习记忆能力的影响。方法:将筛选出的16只雄性SD大鼠随机分为安静对照组(C组,n=8)和运动实验组(T组,n=8),T组进行为期8周的跑台训练。第7周对两组动物分别用Y迷宫进行学习能力测试,第8周进行记忆保持(再现)测试。在最后一次运动24 h后将两组大鼠断髓处死取材,使用RT-PCR法检测各组大鼠海马NR1和NR2BmRNA的表达水平。结果:经过8周跑台运动训练,T组大鼠NR1mRNA的表达量显著高于C组(P<0.01),上调55.1%;T组大鼠NR2BmRNA的表达量显著性高于C组(P<0.01),上调35.6%;Y迷宫测试结果显示,T组大鼠在学习能力和记忆保持测试中的表现均优于C组。结论:8周强制性跑台训练可以易化大鼠空间学习能力,并提高大鼠的空间记忆能力,这可能与运动训练促进了大鼠海马NR1和NR2BmRNA的表达有关。

引用

页码：361 / 365

页数：5

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