凝溶胶蛋白与心血管疾病

被引:11
作者
刘玥
蒋跃绒
殷惠军
陈可冀
机构
[1] 中国中医科学院西苑医院心血管病中心
关键词
凝溶胶蛋白; 肌动蛋白; 血小板活化; 心血管疾病;
D O I
10.16563/j.cnki.1671-6272.2011.01.012
中图分类号
R54 [心脏、血管(循环系)疾病];
学科分类号
100201 [内科学];
摘要
凝溶胶蛋白是一种钙依赖性的肌动蛋白结合蛋白,对肌动蛋白进行切割、加帽、成核以调节细胞骨架结构和细胞的运动及代谢过程,还参与对细胞信号转导和细胞凋亡的调控。大量研究表明凝溶胶蛋白与临床多种疾病的病理过程密切相关,本文重点介绍了凝溶胶蛋白做为潜在的疾病分子标志物或治疗靶点与血小板活化、冠心病、心力衰竭及心律失常等心血管疾病相关性的研究进展。
引用
收藏
页码:50 / 53
页数:4
相关论文
共 11 条
[1]
冠心病血小板功能蛋白与证侯相关性研究 [J].
李雪峰 ;
蒋跃绒 ;
吴彩凤 ;
陈可冀 ;
殷惠军 .
中国分子心脏病学杂志, 2009, 9 (06) :326-331
[2]
Relationship between Platelet Activation Related Factors and Polymorphism of Related Genes in Patients with Coronary Heart Disease of Blood-stasis Syndrome.[J].薛梅;陈可冀;殷惠军;.Chinese Journal of Integrative Medicine.2008, 04
[3]
凝溶胶蛋白的生物学功能及临床意义.[J].王佳;赵卫国;闵锐;.中国危重病急救医学.2009, 04
[4]
Lack of gelsolin promotes perpetuation of atrial fibrillation in the mouse heart [J].
Schrickel, Jan Wilko ;
Fink, Klaus ;
Meyer, Rainer ;
Grohe, Christian ;
Stoeckigt, Florian ;
Tiemann, Klaus ;
Ghanem, Alexander ;
Lickfett, Lars ;
Nickenig, Georg ;
Lewalter, Thorsten .
JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY, 2009, 26 (01) :3-10
[5]
Gelsolin Regulates Cardiac Remodeling After Myocardial Infarction Through DNase I–Mediated Apoptosis.[J].Guo Hua Li;Yu Shi;Yu Chen;Mei Sun;Sawsan Sader;Yuichiro Maekawa;Sara Arab;Fayez Dawood;Manyin Chen;Geoffrey De Couto;Youan Liu;Masahiro Fukuoka;Stanley Yang;Ming Da Shi;Lorrie A. Kirshenbaum;Christopher A. McCulloch;Peter Liu.Circulation Research.2009, 7
[6]
Gelsolin superfamily proteins: key regulators of cellular functions.[J].P. Silacci;L. Mazzolai;C. Gauci;N. Stergiopulos;H. L. Yin;D. Hayoz.Cellular and Molecular Life Sciences.2004, 19
[7]
Caspases as regulators of apoptosis and other cell functions [J].
Philchenkov, AA .
BIOCHEMISTRY-MOSCOW, 2003, 68 (04) :365-376
[8]
Ionic remodeling underlying action potential changes in a canine model of atrial fibrillation [J].
Yue, LX ;
Feng, JL ;
Gaspo, R ;
Li, GR ;
Wang, ZG ;
Nattel, S .
CIRCULATION RESEARCH, 1997, 81 (04) :512-525
[9]
Decreased plasma gelsolin concentrations in acute liver failure, myocardial infarction, septic shock, and myonecrosis [J].
Suhler, E ;
Lin, W ;
Yin, HL ;
Lee, WM .
CRITICAL CARE MEDICINE, 1997, 25 (04) :594-598
[10]
Angiopathic consequences of saturating the plasma scavenger system for actin..Haddad JG; Harper KD; Guoth M; Pietra GG; Sanger JW;.Proc Natl Acad Sci US A.1990,