丹参酮ⅡA与丹皮酚配伍对大鼠脑缺血再灌注损伤保护作用研究

被引：4

作者：

杨倩 ^{[1
]}

郭庆东 ^{[2
]}

谢艳华 ^{[1
]}

周暄宣 ^{[1
]}

李骅 ^{[1
]}

王四旺 ^{[1
]}

机构：

[1] 第四军医大学药学系药物研究所

[2] 第四军医大学西京医院脑科病医院

来源：

现代生物医学进展 | 2011年 / 11卷 / 15期

关键词：

中动脉; 缺血; 再灌注; 脑; 丹参酮ⅡA; 丹皮酚;

D O I：

10.13241/j.cnki.pmb.2011.15.016

中图分类号：

R285.5 [中药实验药理];

学科分类号：

1008 ;

摘要：

目的:研究丹参酮ⅡA与丹皮酚配伍(简称双丹配伍)对大鼠局灶性脑缺血再灌注损伤的脑梗死体积、自由基变化的影响,探讨双丹配伍对脑缺血损伤的保护作用。方法:复制大鼠中动脉缺血再灌注模型,分别给予双丹配伍干预,观察和评价受试动物行为学、脑梗死率、脑指数、脑含水量、SOD、MAD等指标的变化结果:①双丹配伍的各试药组均具有明显改善局灶性脑缺血再灌注损伤大鼠的神经行为学评分,降低脑梗死率、脑指教、脑含水量、提高脑组织SOD活性、降低MDA含量;②双丹配伍各组中1:3配伍组的总体药效作用优于1:2和1:4组,但数据未见统计学差异;③双丹配伍尾静脉注射的药效作用明显优于预先灌胃组。结论:双丹配伍脂质体给大鼠口服和注射对脑缺血再灌注损伤具有显著保护作用

引用

页码：2814 / 2817

页数：4

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