不同比例的乳酸林格氏液/羟乙基淀粉的目标输液对休克犬凝血的影响

被引：4

作者：

陶建平 ^{[1
]}

屈启才 ^{[1
]}

周臣 ^{[1
]}

思永玉 ^{[1
]}

杨家驹 ^{[1
]}

张军辉 ^{[2
]}

万林骏 ^{[3
]}

机构：

[1] 昆明医科大学第二附属医院麻醉科

[2] 昆明市中医院麻醉科

[3] 昆明医科大学第二附属医院ICU

来源：

昆明医科大学学报 | 2017年 / 38卷 / 01期

关键词：

目标导向输液治疗; 低血容量性休克; 凝血功能;

D O I：

暂无

中图分类号：

R614 [麻醉学];

学科分类号：

100217 [麻醉学];

摘要：

目的探讨不同比例的乳酸林格氏液/羟乙基淀粉的目标导向输液治疗对失血性休克犬凝血功能的影响.方法将48只健康比格犬随机分为6组（n=8）:1个假手术对照组（S组）及5个实验组.S组仅实施气管内插管并持续泵入乳酸林格氏液与羟乙基淀粉各1 m L/（kg·h）.实验组犬被制作成失血性休克模型后,按液体复苏时输入乳酸林格氏液与羟乙基淀粉的比例不同随机分为5组:3∶1组、2∶1组、1∶1组、1∶2组及1∶3组.实验组犬的输液目标为每搏量变异度达到8%10%,输血目标为血红蛋白达到10～11 g/L.各组犬都被复苏并观察4 h.抽血检测实验前基础值（T0）、休克后1 h（T1）、复苏2 h（T2）及复苏4 h（T4）时的凝血功能（PT,APTT,TT及Fib）.术毕记录并统计乳酸林格氏液量、羟乙基淀粉液量、总输液量（乳酸林格氏液量+羟乙基淀粉液量）及尿量.结果各组各时点的凝血功能（PT,APTT,TT及Fib）的差异无统计学意义.1∶3组及1∶2组的羟乙基淀粉液量少于3∶1组;1∶3组及1∶2组的乳酸林格氏液量、总输液量和尿量少于3∶1组（P<0.05）.结论乳酸林格氏液和6%羟乙基淀粉比例为3∶1,2∶1,1∶1,1∶2和1∶3的目标输液并不影响失血性休克犬的凝血功能.

引用

页码：51 / 56

页数：6

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