高密度脂蛋白在动脉粥样硬化相关免疫和炎症反应中的双重作用

被引：16

作者：

赵战芝

姜志胜

机构：

[1] 南华大学心血管病研究所

来源：

中国动脉硬化杂志 | 2007年 / 12期

关键词：

病理学与病理生理学; 高密度脂蛋白; 炎症反应; 免疫反应; 动脉粥样硬化;

D O I：

暂无

中图分类号：

R543.5 [动脉疾病];

学科分类号：

1002 ; 100201 ;

摘要：

高密度脂蛋白通过减少细胞因子释放、粘附分子表达、抑制白细胞迁移至动脉壁、中和脂多糖的细胞毒作用、抑制巨噬细胞的抗原提呈功能而抑制炎症和免疫反应。高密度脂蛋白中的载脂蛋白AI、J、M及相关分子鞘氨醇磷酸胆碱等在其中起重要作用。高密度脂蛋白因此而成为组装参与免疫和炎症反应的蛋白平台。而冠心病人高密度脂蛋白的组成和性质发生了改变,促进炎症反应。关注高密度脂蛋白的不同性质,利用它的抗炎、抗动脉粥样硬化一面,可预测和防治冠心病。

引用

页码：953 / 957

页数：5

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