癫癎持续状态对发育期大鼠学习记忆及海马磷酸化的c-AMP反应元件结合蛋白表达的影响

被引：2

作者：

王秀利

唐洪丽

索国玲

机构：

[1] 东南大学附属中大医院儿科

来源：

实用儿科临床杂志 | 2007年 / 22期

关键词：

癫癎持续状态; 学习记忆; c-AMP反应元件结合蛋白; Morris水迷宫; Y迷宫;

D O I：

暂无

中图分类号：

R742.1 [癫痫];

学科分类号：

1002 ;

摘要：

目的探讨癫癎持续状态(SE)对发育期大鼠学习记忆功能及海马磷酸化的c-AMP反应元件结合蛋白(pCREB)表达的影响。方法6周龄SD大鼠32只随机分为SE组和9g/L盐水对照组(NS组)。戊四氮(PTZ)诱导发育期大鼠SE。采用Morris水迷宫和Y迷宫观察大鼠学习记忆功能的改变,应用免疫组织化学方法检测大鼠海马各区pCREB的表达。结果与NS组比较,SE组在Morris水迷宫测试中平均逃避潜伏期明显延长(P<0.05),原平台所在象限的游泳时间明显缩短(P<0.05);Y迷宫中达标所需的训练次数显著增多(P<0.05),24h记忆保持率明显降低(P<0.05)。海马CA1区和齿状回(DG)区pCREB表达显著下调(P<0.05)。结论SE可使发育期大鼠学习记忆功能受损,其机制可能与海马pCREB表达减少有关。

引用

页码：1723 / 1725

页数：3

共 19 条

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