黄酮类化合物调节肥胖相关炎症的研究进展

被引：9

作者：

温馨 ^{[1
]}

王兴亚 ^{[2
]}

孙崇德 ^{[1
]}

李鲜 ^{[1
]}

机构：

[1] 浙江大学浙江省园艺植物整合生物学研究与应用重点实验室

[2] 浙江中医药大学药学院

来源：

中草药 | 2017年 / 48卷 / 14期

基金：

浙江省自然科学基金;

关键词：

肥胖; 炎症; 黄酮类化合物; 代谢疾病; 巨噬细胞; 抗氧化;

D O I：

暂无

中图分类号：

R285 [中药药理学];

学科分类号：

100806 [中药药理学];

摘要：

随着人们生活水平的提高,肥胖人口数量急剧增加。肥胖可诱导巨噬细胞浸润到脂肪组织,产生一系列生理变化,进而引发慢性炎症,并可进一步发展成代谢综合征、心血管疾病等多种慢性疾病。黄酮类化合物广泛存在于植物中,大量研究表明,黄酮类化合物可通过抑制巨噬细胞的浸润、调节信号转导及抗氧化等途径抑制肥胖相关炎症,并降低与其相关慢性疾病的发生风险。从肥胖诱导炎症相关的发病机制出发,概述近年来黄酮类物质抑制肥胖所诱导的慢性炎症的作用机制研究进展。黄酮类化合物在调控代谢炎症及其相关疾病方面有广阔应用前景,筛选更多有效的黄酮类化合物并研究其作用机制,具有重要的理论与临床应用价值。

引用

页码：2972 / 2978

页数：7

共 39 条

[1]

TNF and ROS Crosstalk in Inflammation.[J].Heiko Blaser;Catherine Dostert;Tak W. Mak;Dirk Brenner.Trends in Cell Biology.2016, 4

[2]

Red-fleshed sweet orange juice improves the risk factors for metabolic syndrome [J].

Silveira, Jacqueline Q. ;

Dourado, Grace K. Z. S. ;

Cesar, Thais B. .

INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION, 2015, 66 (07) :830-836

[3]

Dietary Flavonoids Added to Pharmacological Antihypertensive Therapy are Effective in Improving Blood Pressure [J].

de Jesus Romero-Prado, Marina Maria ;

Aaron Curiel-Beltran, Jesus ;

Viviana Miramontes-Espino, Maria ;

German Cardona-Munoz, Ernesto ;

Rios-Arellano, Angeles ;

Balam-Salazar, Lol-Be .

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2015, 117 (01) :57-64

[4]

Quercetin Protects against Obesity-Induced Skeletal Muscle Inflammation and Atrophy.[J].Ngoc Hoan Le;Chu-Sook Kim;Taesun Park;Jung Han Yoon Park;Mi-Kyung Sung;Dong Gun Lee;Sun-Myung Hong;Suck-Young Choe;Tsuyoshi Goto;Teruo Kawada;Rina Yu;Giuseppe Valacchi.Mediators of Inflammation.2014,

[5]

The anti-inflammation effect of baicalin on experimental colitis through inhibiting TLR4/NF-κB pathway activation [J].

Cui, Li ;

Feng, Liang ;

Zhang, Zhen Hai ;

Jia, Xiao Bin .

INTERNATIONAL IMMUNOPHARMACOLOGY, 2014, 23 (01) :294-303

[6]

Epigallocatechin gallate prevents inflammation by reducing macrophage infiltration and inhibiting tumor necrosis factor-α signaling in the pancreas of rats on a high-fat diet [J].

Cao, Yanli ;

Bao, Suqing ;

Yang, Wanli ;

Zhang, Jin ;

Li, Lin ;

Shan, Zhongyan ;

Teng, Weiping .

NUTRITION RESEARCH, 2014, 34 (12) :1066-1074

[7]

Naringenin suppresses macrophage infiltration into adipose tissue in an early phase of high-fat diet-induced obesity.[J].Hiroki Yoshida;Hideaki Watanabe;Akiko Ishida;Wataru Watanabe;Keiko Narumi;Toshiyuki Atsumi;Chihiro Sugita;Masahiko Kurokawa.Biochemical and Biophysical Research Communications.2014,

[8]

Luteolin Inhibits Hyperglycemia-Induced Proinflammatory Cytokine Production and Its Epigenetic Mechanism in Human Monocytes [J].

Kim, Hye Joo ;

Lee, Wooje ;

Yun, Jung-Mi .

PHYTOTHERAPY RESEARCH, 2014, 28 (09) :1383-1391

[9]

Quercetin; Luteolin; and Epigallocatechin Gallate Promote Glucose Disposal in Adipocytes with Regulation of AMP-Activated Kinase and/or Sirtuin 1 Activity.[J].Na Xiao;Fan Mei;Yan Sun;Guojun Pan;Baolin Liu;Kang Liu.Planta Med.2014,

[10]

Regular consumption of Fiit-ns; a polyphenol extract from fruit and vegetables frequently consumed within the Mediterranean diet; improves metabolic ageing of obese volunteers: a randomized; double-blind; parallel trial.[J].Julien Cases;Cindy Romain;Constantin Dallas;Alain Gerbi;Maurice Cloarec.International Journal of Food Sciences and Nutrit.2014, 1

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