钙阻断剂伊拉地平在帕金森病大鼠模型中的神经保护作用

被引：8

作者：

胡明 ^{[1
]}

陈国华 ^{[1
]}

刘昌勤 ^{[2
]}

机构：

[1] 武汉市第一医院神经内科

[2] 华中科技大学同济医学院附属协和医院神经内科

来源：

华中科技大学学报(医学版) | 2012年 / 41卷 / 05期

关键词：

钙阻断剂; 伊拉地平; 帕金森病; 神经保护; 6-羟基多巴胺;

D O I：

暂无

中图分类号：

R742.5 [震颤麻痹综合征];

学科分类号：

100204 [神经病学];

摘要：

目的利用6-羟基多巴胺(6-OHDA)损毁的大鼠帕金森病(PD)模型,研究钙阻断剂伊拉地平对神经元的保护作用。方法大鼠给予伊拉地平1周后,纹状体内注射6-OHDA造模,然后继续给药2周。用圆柱体试验和旋转试验评价损毁程度,用酪氨酸羟化酶(TH)免疫组化染色计数多巴胺神经元数量。结果行为学测试表明,伊拉地平预给药大鼠运动功能障碍有所改善。免疫组化染色显示,用药组黑质多巴胺能神经元较模型组显著增多,提示伊拉地平预给药具有神经保护作用。另1组动物在损毁后给药则没有明显改善。结论伊拉地平有希望成为具有神经保护作用的新型抗PD药物。

引用

页码：581 / 584

页数：4

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