雌激素对脑卒中后抑郁大鼠抑郁行为学及前额叶BDNF表达的影响

被引：5

作者：

苏巧尔 ^{[1
]}

邵蓓 ^{[1
]}

金坤林 ^{[1
,2
]}

程建华 ^{[1
]}

程一帆 ^{[1
]}

林真珍 ^{[1
]}

王柳青 ^{[1
]}

机构：

[1] 温州医学院附属第一医院脑血管科

[2] 温州医学院附属第一医院神经外科

来源：

中国临床神经科学 | 2012年 / 20卷 / 01期

关键词：

雌激素; 脑卒中后抑郁; 脑源性生长因子; 前额叶; 大鼠;

D O I：

暂无

中图分类号：

R749.1 [脑器质性精神障碍];

学科分类号：

摘要：

目的:探讨雌激素对脑卒中后抑郁(PSD)大鼠的影响及分子机制。方法:应用大脑中动脉栓塞和慢性不可预见温和刺激方法制备大鼠PSD模型。将PSD大鼠分为雌激素组(PSD大鼠皮下注射雌二醇),PSD组(PSD大鼠皮下注射大豆油)和对照组(假手术,皮下注射大豆油)。3组的不同干预均持续14 d。观察各组大鼠行为学和前额叶脑源性生长因子(BDNF)的含量改变。结果:雌激素组在雌二醇干预后强迫游泳测试结果表明行为学显著改善:不动时间减少,与PSD组比较(18.4±4.84 vs 52.1±5.38)差异有显著统计学意义(P<0.01);雌激素组挣扎时间增加,与PSD组比较(63.8±12.31 vs 36.3±5.22)差异有统计学意义(P<0.05)。前额叶BDNF含量在雌激素组也显著增高:雌激素组与PSD组比较,P<0.05;PSD组与对照组比较,P<0.01。结论:雌激素可能通过BDNF通路改善PSD大鼠的抑郁症状。

引用

页码：43 / 47

页数：5

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