炎症标志物检测在重症感染病原学判断中的意义

被引：12

作者：

王春霞

张育才

机构：

[1] 上海交通大学附属儿童医院重症医学科上海交通大学儿科危重病研究所

来源：

中国小儿急救医学 | 2020年 / 27卷 / 03期

关键词：

感染; 炎症反应; 生物标记物; 病原学;

D O I：

暂无

中图分类号：

R720.597 [儿科急症及处理];

学科分类号：

100202 [儿科学];

摘要：

重症感染及脓毒症是儿童重症监护室(PICU)患者的主要死亡原因。重症感染常起病急、进展快、累及多个器官、病原复杂多样, 如何尽早明确致病病原体对治疗决策制定至关重要。依据重症患儿精准化诊断及个体化治疗策略, 联合分子生物学、多组学分析技术、宏基因组测序等方法使病原学精准诊断成为可能。炎症标记物包括传统炎症因子、急性期反应蛋白、血液特异RNA生物特征谱、代谢小分子、以及免疫细胞标记物等多个维度, 可从多个角度实现对病原微生物的识别。

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