肿瘤免疫逃逸的研究进展

被引：29

作者：

侯清玉

杨秀萍

机构：

[1] 首都师范大学生命科学学院

来源：

中华肿瘤防治杂志 | 2010年 / 17卷 / 03期

关键词：

肿瘤逃逸; 抑制因子,免疫; 综述文献;

D O I：

10.16073/j.cnki.cjcpt.2010.03.021

中图分类号：

R730.3 [肿瘤免疫学与血清学];

学科分类号：

100108 [医学免疫学];

摘要：

目的:探讨肿瘤免疫治疗的方法,指导理论研究和临床应用。方法:应用NCBI的PubMed文献数据库,以"主要组织相容性复合物Ⅰ类分子、调节性T细胞和半乳糖凝集素"等为关键词,检索2005-01-2009-10文献1080篇。纳入标准:1)抗原呈递机制的改造。2)免疫抑制因子。3)免疫调节细胞。4)负向调节途径。5)Fas/FasL的反击。最后纳入分析30篇文献,并加入早期原始文献1篇。结果:肿瘤细胞可通过多种途径逃避机体免疫系统的监视,包括肿瘤诱导的抗原呈递的减弱,免疫抑制因子的上调,增加或补充调节细胞的数量参与到免疫抑制网络,这些细胞包括调节性T细胞,骨髓的抑制性细胞,特殊的成熟和不成熟的调节性树突状细胞的亚群,另外,负向共刺激信号的激活和Fas系统的反击策略也是肿瘤逃避免疫杀伤的基本手段。结论:肿瘤免疫逃避机制的多样性,决定了抗肿瘤免疫治疗的复杂性,采取有效的抗肿瘤策略,对于临床免疫治疗将有着积极的作用。

引用

收藏

页码：228 / 232

页数：5

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