文拉法辛、艾司西酞普兰对抑郁症患者痛觉诱发电位P250的影响

被引：3

作者：

纪菊英

潘园园

徐乐平

李宁

孙剑

机构：

[1] 解放军第医院精神科

来源：

临床精神医学杂志 | 2012年 / 22卷 / 05期

关键词：

文拉法辛; 艾司西酞普兰; 诱发电位; 痛觉; 抑郁症;

D O I：

暂无

中图分类号：

R749.4 [情感性精神病];

学科分类号：

100204 [神经病学];

摘要：

目的:探讨不同作用机制的抗抑郁药文拉法辛、艾司西酞普兰对抑郁症患者电刺激痛觉诱发电位P250的影响。方法:52例抑郁症患者随机分组,分别接受文拉法辛(26例,75～225mg/d)、艾司西酞普兰(26例,10～20mg/d)治疗,于治疗前、治疗后2周末测定电刺激痛觉诱发电位P250,评定17项汉密尔顿抑郁量表(HAMD)。结果:文拉法辛组治疗前P250波幅为(33±10)μV,治疗后下降为(27±7)μV,差异有统计学意义(P=0.000);西酞普兰组治疗前P250波幅为(35±8)μV,治疗后为(34±9)μV,差异无统计学意义(P=0.091);两组治疗前后P250峰潜伏期差异均无统计学意义(P=0.417、0.562)。文拉法辛组治疗后的P250波幅下降率为(18±11)%,高于艾司西酞普兰组的(3±7)%,差异有统计学意义(P=0.000)。两组治疗后HAMD减分率分别为(24±4)%、(26±5)%,差异无统计学意义(P=0.166)。文拉法辛组、艾司西酞普兰组P250波幅下降率与HAMD减分率相关均无统计学意义(r=0.233,P=0.291;r=0.266,P=0.198)。结论:文拉法辛可下调抑郁症患者电刺激痛觉诱发电位P250波幅,其作用强于艾司西酞普兰、并可能独立于抗抑郁效应。

引用

页码：322 / 325

页数：4

共 13 条

[1]

Depression and changed pain perception: Hints for a central disinhibition mechanism [J].

Klauenberg, Sabrina ;

Maier, Christoph ;

Assion, Hans-Joerg ;

Hoffmann, Axel ;

Krumova, Elena K. ;

Magerl, Walter ;

Scherens, Andrea ;

Treede, Rolf-Detlef ;

Juckel, Georg .

PAIN, 2008, 140 (02) :332-343

[2]

The association of depression and neuroticism with pain reports: A comparison of momentary and recalled pain assessment [J].

Raselli, Carla ;

Broderick, Joan E. .

JOURNAL OF PSYCHOSOMATIC RESEARCH, 2007, 62 (03) :313-320

[3]

Serotonin noradrenaline reuptake inhibitors: New hope for the treatment of chronic pain.[J].Pedro L. Delgado.International Journal of Psychiatry in Clinical P.2006, S2

[4]

Analgesic effects of serotonergic; noradrenergic or dual reuptake inhibitors in the carrageenan test in rats: Evidence for synergism between serotonergic and noradrenergic reuptake inhibition.[J].Carrie K. Jones;Brian J. Eastwood;Anne B. Need;Harlan E. Shannon.Neuropharmacology.2006, 7

[5]

The pain-evoked P2 is not a P3a event-related potential [J].

Dowman, R .

BRAIN TOPOGRAPHY, 2004, 17 (01) :3-12

[6]

Differential morphine effects on short- and long-latency laser-evoked cortical responses in the rat [J].

Tsai, ML ;

Kuo, CC ;

Sun, WZ ;

Yen, CT .

PAIN, 2004, 110 (03) :665-674

[7]

Amplitudes of laser evoked potential recorded from primary somatosensory; parasylvian and medial frontal cortex are graded with stimulus intensity.[J].S Ohara;N.E Crone;N Weiss;R.-D Treede;F.A Lenz.Pain.2004, 1

[8]

Distraction produces an increase in pain-evoked anterior cingulate activity [J].