自身免疫性甲状腺炎实验动物模型的研究进展

被引：45

作者：

邓莉 ^{[1
]}

孙文 ^{[2
]}

侯毅 ^{[2
]}

刘铜华 ^{[2
]}

机构：

[1] 陕西中医药大学

[2] 北京中医药大学

来源：

天津中医药 | 2016年 / 33卷 / 03期

关键词：

自身免疫性甲状腺炎; 动物模型; 综述;

D O I：

暂无

中图分类号：

R581.4 [甲状腺炎]; R-332 [医用实验动物学];

学科分类号：

100201 [内科学]; 100402 [劳动卫生与环境卫生学];

摘要：

自身免疫性甲状腺炎(AIT)是一种常见的器官特异性自身免疫疾病。目前,AIT发病机制还不明确,阻碍了新的有效治疗方法的研发,AIT动物模型的开发应用是AIT研究的重要手段。AIT的动物模型方法主要有异源性甲状腺抗原免疫法、脾细胞体外活化移植诱导法、重组促甲状腺素受体(TSHR)多肽免疫法、cDNA疫苗免疫法、高碘诱发法及自发性模型。通过对其动物模型研究进展进行讨论,旨在建立一个经济、有效的动物模型,以求进一步系统研究自身免疫甲状腺病(AITD)的发病机制及防治。

引用

页码：189 / 192

页数：4

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