Effects of Green Tea Polyphenols on Iodide-Induced Autoimmune Thyroiditis In Nonobese Diabetic Mice

被引：14

作者：

Hoshikawa, Saeko ^{[1
]}

Nakagawa, Yoshinori ^{[1
]}

Ozaki, Hiroshi ^{[1
]}

Takahashi, Yurie ^{[1
]}

Ito, Sadayoshi ^{[1
]}

Yoshida, Katsumi ^{[2
]}

Mori, Kouki ^{[3
]}

机构：

[1] Tohoku Univ, Grad Sch Med, Div Nephrol Endocrinol & Vasc Med, Sendai, Miyagi 9808574, Japan

[2] KKR Tohoku Kosai Hosp, Healthy Med Ctr, Sendai, Miyagi 9800804, Japan

[3] JR Sendai Hosp, Ctr Hlth Promot, Sendai, Miyagi 9808508, Japan

来源：

IMMUNOLOGICAL INVESTIGATIONS | 2013年 / 42卷 / 03期

关键词：

Green tea polyphenols; Hashimoto's thyroiditis; Nonobese diabetic mouse; Iodide; SYNTHETIC RETINOID AM80; HUMAN SJOGRENS-SYNDROME; NOD MICE; MURINE MODEL; T-CELLS; EPIGALLOCATECHIN-3-GALLATE; PREVENTION; EXTRACT; SUPPRESSION; CONSUMPTION;

D O I：

10.3109/08820139.2012.753611

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Because green tea polyphenols (GTPs) possess anti-inflammatory properties and are effective in inhibiting autoimmune diseases in experimental settings, we examined whether GTPs prevented the development of autoimmune thyroiditis in iodide-treated nonobese diabetic (NOD) mice, an animal model of Hashimoto's thyroiditis (HT). Mice were given 0.05% iodide water or iodide water supplemented with 0.2% GTPs for 8 weeks. GTPs administration led to an enhanced production of interleukin-10 by concanavalin A-stimulated splenocytes but did not interfere with thyroiditis development. Serum thyroxine levels were not influenced by GTPs. Our data suggest that administration of GTPs may not be an effective strategy for the prevention of HT.

引用

页码：235 / 246

页数：12

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