活性氧对NF-κB活性及JNK信号通路的调节

被引：10

作者：

李芊芊

彭双清

机构：

[1] 中国人民解放军疾病预防控制所

来源：

生物技术通讯 | 2008年 / 04期

关键词：

活性氧; κ基因结合核因子; c-JunN端激酶; 信号通路;

D O I：

暂无

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

活性氧(ROS)是生物体有氧代谢过程中产生的一类活性含氧化合物的总称,机体细胞可通过多种途径维持ROS产生与降解的动态平衡。研究表明,活性氧可作为第二信使调节与细胞增殖、分化、凋亡相关的信号转导通路。c-JunN端激酶(JNK)通路可以介导氧化应激、细胞因子、紫外照射等引起的细胞凋亡。另外,κ基因结合核因子(NF-κB)是氧化应激调节的靶因子之一,同样也能诱导促进细胞内的氧化应激反应,还可通过活性氧蓄积抑制JNK的激活。简要综述活性氧对NF-κB和JNK信号通路的调节。

引用

页码：611 / 614

页数：4

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