Oxygen sensing and oxidant/redox-related pathways

被引:104
作者
Haddad, JJ [1 ]
机构
[1] Univ Calif San Francisco, Severinghaus, Radiometer Res Labs, San Francisco, CA 94143 USA
基金
英国惠康基金; 英国医学研究理事会; 美国国家卫生研究院;
关键词
glutathione; HIF-1; alpha; hyperoxia; hypoxia; NF-kappa B; oxygen sensing; transcription factor; redox equilibrium;
D O I
10.1016/j.bbrc.2004.02.162
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
What is the nature of the oxygen sensor(s) and how do organisms sense variations in oxygen? A progressive rise of oxidative stress due to the altered reduction-oxidation (redox) homeostasis appears to be one of the hallmarks of the processes that regulate gene transcription. Dynamic changes in oxygen homeostasis and its close association with redox equilibrium, therefore, constitute a signaling mechanism for the expression/activation of oxygenes. This variation subsequently regulates the compartmentalization and functioning of HIF-1alpha and NF-kappaB. In addition, oxygen-evoked regulation of HIF-1alpha and NF-kappaB is closely coupled with intracellular redox state, such that modulating redox equilibrium affects their responsiveness at the molecular level (expression/transactivation). Interestingly, are these particular transcription factors potential oxygen sensors? The basic components of the intracellular oxidative/redox machinery and its crucial regulation of oxygen- and redox-sensitive transcription factors may help understand the network of oxygen sensing mechanisms and redox-related pathways. (C) 2004 Published by Elsevier Inc.
引用
收藏
页码:969 / 977
页数:9
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