肿瘤细胞恶性增殖和细胞周期调控改变的分子机制

被引:15
作者
马晓方 [1 ]
杜晓光 [2 ]
辛现良 [2 ]
耿美玉 [1 ,2 ]
机构
[1] 中国海洋大学医药学院分子药理实验室
[2] 中国科学院上海药物所国家药物研究重点实验室肿瘤药理部
关键词
肿瘤; 细胞周期; 信号转导; 周期调节蛋白;
D O I
10.13241/j.cnki.pmb.2009.05.059
中图分类号
R730.2 [肿瘤病理学、病因学];
学科分类号
摘要
真核细胞通过复杂的细胞周期调控系统控制细胞的分裂,从而维持有机体的正常代谢和增殖。细胞周期的调控是由一系列重要的信号分子和周期蛋白家族来完成的,这些调节因子发生突变或者表达水平发生改变,将导致细胞周期调控的改变,使细胞增殖能力增强、分化减弱,丧失细胞原有的功能,最终发展成肿瘤细胞。因此细胞周期及其相关调控蛋白和信号机制成为抗肿瘤研究的热点。
引用
收藏
页码:950 / 953
页数:4
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