化疗和放疗对可切除性胃癌的临床治疗研究进展

被引：13

作者：

万平 ^{[1
,2
,3
]}

燕敏 ^{[1
,2
,3
]}

严超 ^{[1
,2
,3
]}

毕任达 ^{[1
,2
,3
]}

李琛 ^{[1
,2
,3
]}

机构：

[1] 上海交通大学医学院附属瑞金医院外科

[2] 上海市消化外科研究所

[3] 上海交通大学医学院

来源：

中华胃肠外科杂志 | 2012年 / 02期

关键词：

胃肿瘤; 化学疗法; 放射疗法;

D O I：

暂无

中图分类号：

R735.2 [胃肿瘤];

学科分类号：

100112 [医学生物化学与分子生物学];

摘要：

基于各项Ⅲ期临床研究,近年来,术后化放疗、围手术期ECF方案(表柔比星、顺铂和氟尿嘧啶)化疗以及术后口服S-1辅助化疗分别成为了美国、欧洲和日本治疗可切除性胃癌的标准辅助治疗方式。2001年,美国西南肿瘤组(SWOG)报道的大型Ⅲ期随机临床试验(INT0116)结果,使得术后化放疗在美国成为可切除性胃癌的标准治疗方式。随着化放疗技术的快速发展,术前化放疗、术后化放疗、化放疗联合术中放疗等各种化放疗方案不断地被业内学者所报道。本综述总结近年来报道的关于胃癌患者手术前后的辅助性化放疗方案及其临床试验结果,并综合评价化放疗在可切除性胃癌中的治疗价值及意义。

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