女贞子及其活性成分抗骨质疏松症的研究进展

被引：58

作者：

张明发

沈雅琴

机构：

[1] 上海美优制药有限公司

来源：

药物评价研究 | 2014年 / 37卷 / 06期

关键词：

女贞子; 骨质疏松; 齐墩果酸; 熊果酸; 红景天苷;

D O I：

暂无

中图分类号：

R285.5 [中药实验药理];

学科分类号：

100806 [中药药理学];

摘要：

女贞子提取物及其活性成分齐墩果酸、熊果酸、红景天苷等对去卵巢大小鼠,雌性老龄大鼠均具有抗骨质疏松作用,能抗糖皮质激素引起的或糖尿病并发的骨质疏松以及胶原性关节炎大鼠的骨质破坏。它们的作用机制可能是通过(1)促进成骨细胞分化,抑制基质金属蛋白酶表达,阻滞破骨细胞激活;(2)促进活性维生素D3生物合成以及维生素D受体和钙结合蛋白表达,促进肠钙吸收,抑制尿钙排泄,提高骨密度,产生抗骨质疏松的防治作用。综述了女贞子及其活性成分抗骨质疏松作用的研究进展,为新药研发提供依据。

引用

页码：566 / 571

页数：6

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