NF-κB激活的调节机理

被引：21

作者：

陈丹英

翟中和

舒红兵

不详

机构：

[1] 北京大学生命科学学院

[2] 北京大学生命科学学院北京

[3] 北京

[4] 北京 National Jewish Medical and Research Center

[5] Denver

[6] CO

[7] USA

来源：

科学通报 | 2003年 / 18期

关键词：

NF-κB; IKK; 泛素; TNF-R1; TLR; 细胞凋亡; 信号转导;

D O I：

暂无

中图分类号：

Q26 [细胞生物化学];

学科分类号：

071009 ; 090102 ;

摘要：

NF-κB是广泛存在于各种类型细胞中的一种转录因子.它调节大量与细胞应急反应,如免疫应答、炎症反应和细胞抗凋亡作用相关的基因的转录.NF-κB活化的失调与许多人类病症如类风湿性关节炎、癌症等直接相关,因此NF-κB激活的调节机制一直是细胞生物学及免疫学领域的研究热点.NF-κB通常与抑制因子IκBs相结合,以非活性形式存在于细胞质中,当细胞受到上游刺激因子,如肿瘤坏死因子、白介素-1、细菌脂多糖等的作用时,IκB在激酶复合物IKK的作用下被磷酸化,进而被泛素连接酶复合物E3RSIκB/β-TrCP识别并泛素化,然后被26S蛋白酶体识别并迅速降解.IκB的降解使NF-κB的核定位序列暴露出来,进入核内起始转录.IKK的活化是NF-κB激活信号通路中的关键步骤,同时NF-κB的磷酸化、NF-κB前体的降解等也在其中发挥重要作用.本文重点介绍NF-κB激活调节的经典途径及最新研究进展.

引用

页码：1893 / 1911

页数：19

共 46 条

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