肠易激综合征的发病机制研究进展

被引:56
作者
彭珊
赵钢
李春艳
机构
[1] 大连医科大学附属一院消化科
关键词
肠易激综合征; 发病机制; 动力异常; 内脏高敏感性;
D O I
暂无
中图分类号
R574.4 [肠道功能紊乱];
学科分类号
1002 ; 100201 ;
摘要
肠易激综合征(IBS)是一种以腹痛或腹部不适伴排便习惯改变为特征的功能性胃肠病,其发病机制尚未完全阐明。近年来对IBS发病机制的研究取得了实质性进展,认为IBS由多种因素引起,包括异常肠道黏膜细胞及神经递质、胃肠动力、内脏高敏感、肠道感染、小肠细茵过度生长、脑肠轴、精神心理因素、饮食因素等。
引用
收藏
页码:54 / 57
页数:4
相关论文
共 23 条
[11]   Altered brain responses in subjects with irritable bowel syndrome during cued and uncued pain expectation [J].
Hong, J. -Y. ;
Naliboff, B. ;
Labus, J. S. ;
Gupta, A. ;
Kilpatrick, L. A. ;
Ashe-McNalley, C. ;
Stains, J. ;
Heendeniya, N. ;
Smith, S. R. ;
Tillisch, K. ;
Mayer, E. A. .
NEUROGASTROENTEROLOGY AND MOTILITY, 2016, 28 (01) :127-138
[12]   Aberrant mucosal lymphocyte number and subsets in the colon of post-infectious irritable bowel syndrome patients [J].
Sundin, Johanna ;
Rangel, Ignacio ;
Kumawat, Ashok K. ;
Hultgren-Hornquist, Elisabeth ;
Brummer, Robert J. .
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 2014, 49 (09) :1068-1075
[13]  
Colonic Mucosal Immune Activity in Irritable Bowel Syndrome: Comparison with Healthy Controls and Patients with Ulcerative Colitis[J] . Ji Yong Ahn,Kyung Hun Lee,Chang Hwan Choi,Ju Wan Kim,Hyun Woong Lee,Jeong Wook Kim,Mi Kyung Kim,Gui Young Kwon,Seungbong Han,Seong-Eun Kim,Sung Min Kim,Sae Kyung Chang.Digestive Diseases and Sciences . 2014 (5)
[14]   Neuroimmune interactions at different intestinal sites are related to abdominal pain symptoms in children with IBS [J].
Di Nardo, G. ;
Barbara, G. ;
Cucchiara, S. ;
Cremon, C. ;
Shulman, R. J. ;
Isoldi, S. ;
Zecchi, L. ;
Drago, L. ;
Oliva, S. ;
Saulle, R. ;
Barbaro, M. R. ;
Stronati, L. .
NEUROGASTROENTEROLOGY AND MOTILITY, 2014, 26 (02) :196-204
[15]  
Mast cell number, substance P and vasoactive intestinal peptide in irritable bowel syndrome with diarrhea[J] . Won Sohn,Oh Young Lee,Sang Pyo Lee,Kang Nyeong Lee,Dae Won Jun,Hang Lak Lee,Byung Chul Yoon,Ho Soon Choi,Jongmin Sim,Ki-Seok Jang.Scandinavian Journal of Gastroenterology . 2013 (1)
[16]  
Diagnosis, Comorbidities, and Management of Irritable Bowel Syndrome in Patients in a Large Health Maintenance Organization[J] . Uri Ladabaum,Erin Boyd,Wei K. Zhao,Ajitha Mannalithara,Annie Sharabidze,Gurkirpal Singh,Elaine Chung,Theodore R. Levin.Clinical Gastroenterology and Hepatology . 2012 (1)
[17]   Genetic Risk Factors for Post-Infectious Irritable Bowel Syndrome Following a Waterborne Outbreak of Gastroenteritis [J].
Villani, Alexandra-Chloe ;
Lemire, Mathieu ;
Thabane, Marroon ;
Belisle, Alexandre ;
Geneau, Genevieve ;
Garg, Amit X. ;
Clark, William F. ;
Moayyedi, Paul ;
Collins, Stephen M. ;
Franchimont, Denis ;
Marshall, John K. .
GASTROENTEROLOGY, 2010, 138 (04) :1502-1513
[18]  
Role of serotonin in gastrointestinal motility and irritable bowel syndrome[J] . Arbab Sikander,Satya Vati Rana,Kaushal Kishor Prasad.Clinica Chimica Acta . 2009 (1)
[19]   Altered rectal perception in irritable bowel syndrome is associated with symptom severity [J].
Posserud, Iris ;
Syrous, Alma ;
Lindstrom, Lina ;
Tack, Jan ;
Abrahamsson, Hasse ;
Simren, Magnus .
GASTROENTEROLOGY, 2007, 133 (04) :1113-1123
[20]   Functional bowel disorders [J].
Longstreth, George F. ;
Thompson, W. Grant ;
Chey, William D. ;
Houghton, Lesley A. ;
Mearin, Fermin ;
Spiller, Robin C. .
GASTROENTEROLOGY, 2006, 130 (05) :1480-1491