不同运动方式对小鼠骨骼肌肌萎缩相关因子表达的影响

被引：21

作者：

陈彩珍 ^{[1
,2
]}

卢健 ^{[1
,2
]}

季浏 ^{[1
,2
]}

机构：

[1] 华东师范大学青少年健康评价与运动干预教育部重点实验室

[2] 华东师范大学体育与健康学院

来源：

沈阳体育学院学报 | 2014年 / 33卷 / 05期

关键词：

肌萎缩; 泛素蛋白酶体途径; IGF-1; MuRF-1; MAFbx; Caspase-3; 耐力训练; 抗阻训练;

D O I：

暂无

中图分类号：

G804.2 [运动生理学];

学科分类号：

040211 [体育与运动心理学];

摘要：

目的:运动能够引起骨骼肌肥大,防止肌萎缩的发生。骨骼肌在萎缩状态下泛素蛋白酶通路被激活,旨在通过检测蛋白降解途径中几个关键因子mRNA的表达,探讨不同的运动形式对抗骨骼肌萎缩的效果及机制。方法:选取21只雄性老年SAMP8小鼠,随机分为对照组(C)、耐力训练组(E)、抗阻训练组(R)。经过8周的训练后,检测小鼠右侧腓肠肌横截面积及MuRF-1、MAFbx、Caspase-3和IGF-1mRNA表达。结果:耐力训练和抗阻训练大鼠腓肠肌MuRF-1、MAFbx和Caspase-3 mRNA表达均显著高于对照组,但两训练组间无显著性差异;IGF-1mRNA的表达两训练组亦显著高于对照组,且抗阻训练组显著高于耐力训练组,抗阻训练组的腓肠肌纤维面积显著高于对照组和耐力训练组。结论:抗阻训练在维持肌质量方面效果优于耐力训练。两种不同的运动方式对腓肠肌质量影响之差异可能不仅仅是通过泛素蛋白酶体途径实现,还与IGF-1介导的骨骼肌再生有关。

引用

页码：85 / 89

页数：5

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