The effects of aging, physical training, and a single bout of exercise on mitochondrial protein expression in human skeletal muscle

被引：95

作者：

Bori, Zoltan ^{[1
]}

Zhao, Zhongfu ^{[1
,2
]}

Koltai, Erika ^{[1
]}

Fatouros, Ioannis G. ^{[3
]}

Jamurtas, Athanasios Z. ^{[4
]}

Douroudos, Ioannis I. ^{[3
]}

Terzis, Gerasimos ^{[5
]}

Chatzinikolaou, Athanasios ^{[3
]}

Sovatzidis, Apostolos ^{[6
]}

Draganidis, Dimitrios ^{[3
]}

Boldogh, Istvan ^{[7
]}

Radak, Zsolt ^{[1
]}

机构：

[1] Semmelweis Univ, Res Inst Sport Sci, H-1085 Budapest, Hungary

[2] Changzhi Med Coll, Inst Hepatol, Shanxi, Peoples R China

[3] Democritus Univ Thrace, Dept Phys Educ & Sport Sci, Komotini, Greece

[4] Univ Thessaly, Dept Phys Educ & Sport Sci, Trikala, Greece

[5] Univ Athens, Lab Athlet, Sch Phys Educ & Sport Sci, Athens, Greece

[6] Democritus Univ Thrace, Sch Med, Alexandroupolis, Greece

[7] Univ Texas Med Branch Galveston, Galveston, TX 77555 USA

来源：

EXPERIMENTAL GERONTOLOGY | 2012年 / 47卷 / 06期

关键词：

Aging; Exercise; Skeletal muscle; Mitochondrial biogenesis; Fusion and fission; POLYNUCLEOTIDE PHOSPHORYLASE HPNPASE(OLD-35); OXIDATIVE STRESS; ACTIVITY QUESTIONNAIRE; FUSION; FISSION; GENE; GLYCOSYLASE; PERFORMANCE; BIOGENESIS; METABOLISM;

D O I：

10.1016/j.exger.2012.03.004

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

030301 [社会学]; 100201 [内科学];

摘要：

Aging results in a significant decline in aerobic capacity and impaired mitochondrial function. We have tested the effects of moderate physical activity on aerobic capacity and a single bout of exercise on the expression profile of mitochondrial biogenesis, and fusion and fission related genes in skeletal muscle of human subjects. Physical activity attenuated the aging-associated decline in VO2 max (p<0.05). Aging increased and a single exercise bout decreased the expression of nuclear respiratory factor-1 (NRF1), while the transcription factor A (TFAM) expression showed a strong relationship with VO2max and increased significantly in the young physically active group. Mitochondrial fission representing FIS1 was induced by regular physical activity, while a bout of exercise decreased fusion-associated gene expression. The expression of polynucleotide phosphorylase (PNPase) changed inversely in young and old groups and decreased with aging. The A2 subunit of cyclic AMP-activated protein kinase (AMPK) was induced by a single bout of exercise in skeletal muscle samples of both young and old subjects (p<0.05). Our data suggest that moderate levels of regular physical activity increases a larger number of mitochondrial biogenesis-related gene expressions in young individuals than in aged subjects. Mitochondrial fission is impaired by aging and could be one of the most sensitive markers of the age-associated decline in the adaptive response to physical activity. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：417 / 424

页数：8

共 55 条

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