乙型肝炎相关慢加急性肝衰竭的免疫学特征及治疗策略

被引:37
作者
张耿林
高志良
机构
[1] 中山大学附属第三医院
关键词
慢加急性肝衰竭; 乙型肝炎病毒; 免疫损伤; 治疗;
D O I
10.16505/j.2095-0136.2011.01.009
中图分类号
R512.62 [];
学科分类号
摘要
<正>全球约有3.5亿人为乙型肝炎病毒(HBV)慢性感染者,而中国有近1亿人为慢性乙型肝炎患者,有15%40%未经抗病毒治疗的患者将进展为终末期肝病,如肝硬化、肝衰竭及肝癌等[1-3]。在中国,HBV感染相关的慢加急性肝衰竭(acute-on-chronicliver failure,HBV-ACLF)患者约占肝衰竭患者总数
引用
收藏
页码:5 / 8
页数:4
相关论文
共 16 条
[1]
Predictive Parameters After Molecular Absorbent Recirculating System Treatment Integrated With Model for End Stage Liver Disease Model in Patients With Acute-on-Chronic Liver Failure [J].
Novelli, G. ;
Rossi, M. ;
Ferretti, G. ;
Pugliese, F. ;
Travaglia, D. ;
Guidi, S. ;
Novelli, S. ;
Lai, Q. ;
Morabito, V. ;
Berloco, P. B. .
TRANSPLANTATION PROCEEDINGS, 2010, 42 (04) :1182-1187
[2]
Correlation of TLR1-10 expression in peripheral blood mononuclear cells with chronic hepatitis B and chronic hepatitis B-related liver failure [J].
Wang, Ke ;
Liu, Hongli ;
He, Yingli ;
Chen, Tianyan ;
Yang, Yuan ;
Niu, Yinghua ;
Chen, Hongmei ;
Chen, Yunru ;
Liu, Jinfeng ;
Ye, Feng ;
Lin, Shumei ;
Zhao, Yingren .
HUMAN IMMUNOLOGY, 2010, 71 (10) :950-956
[3]
The molecular basis of the failed immune response in chronic HBV: Therapeutic implications [J].
Maini, Mala K. ;
Schurich, Anna .
JOURNAL OF HEPATOLOGY, 2010, 52 (04) :616-619
[4]
Cost-effectiveness of the artificial liver support system MARS in patients with acute-on-chronic liver failure [J].
Hessel, Franz P. ;
Bramlage, Peter ;
Wasem, Juergen ;
Mitzner, Steffen R. .
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 2010, 22 (02) :213-220
[5]
Nucleoside Analogue Can Improve the Long-Term Prognosis of Patients with Hepatitis B Virus Infection-Associated Acute on Chronic Liver Failure [J].
Cui, Yao-Li ;
Yan, Fang ;
Wang, Yue-Bin ;
Song, Xue-Qin ;
Liu, Li ;
Lei, Xue-Zhong ;
Zheng, Ming-Hua ;
Tang, Hong ;
Feng, Ping .
DIGESTIVE DISEASES AND SCIENCES, 2010, 55 (08) :2373-2380
[6]
The Study of Efficacy of Lamivudine in Patients with Severe Acute Hepatitis B [J].
Yu, Jian-Wu ;
Sun, Li-Jie ;
Zhao, Yong-Hua ;
Kang, Peng ;
Li, Shu-Chen .
DIGESTIVE DISEASES AND SCIENCES, 2010, 55 (03) :775-783
[7]
Mesenchymal stem cells suppress B-cell terminal differentiation [J].
Asari, Sadaki ;
Itakura, Shin ;
Ferreri, Kevin ;
Liu, Chih-Pin ;
Kuroda, Yoshikazu ;
Kandeel, Fouad ;
Mullen, Yoko .
EXPERIMENTAL HEMATOLOGY, 2009, 37 (05) :604-615
[8]
Infection and inflammation in liver failure: Two sides of the same coin [J].
Malik, Raza ;
Mookerjee, Rajeshwar P. ;
Jalan, Rajiv .
JOURNAL OF HEPATOLOGY, 2009, 51 (03) :426-429
[9]
EASL Clinical Practice Guidelines: Management of chronic hepatitis B [J].
Marcellin, Patrick ;
Dusheiko, Geoffrey ;
Zoulim, Fabien ;
Esteban, Rafael ;
Hadziyannis, Stefanos ;
Lampertico, Pietro ;
Manns, Michael ;
Shouval, Daniel ;
Yurdaydin, Cihan .
JOURNAL OF HEPATOLOGY, 2009, 50 (02) :227-242
[10]
Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the study of the liver (APASL) [J].
Sarin, Shiv Kumar ;
Kumar, Ashish ;
Almeida, John A. ;
Chawla, Yogesh Kumar ;
Fan, Sheung Tat ;
Garg, Hitendra ;
de Silva, H. Janaka ;
Hamid, Saeed Sadiq ;
Jalan, Rajiv ;
Komolmit, Piyawat ;
Lau, George K. ;
Liu, Qing ;
Madan, Kaushal ;
Mohamed, Rosmawati ;
Ning, Qin ;
Rahman, Salimur ;
Rastogi, Archana ;
Riordan, Stephen M. ;
Sakhuja, Puja ;
Samuel, Didier ;
Shah, Samir ;
Sharma, Barjesh Chander ;
Sharma, Praveen ;
Takikawa, Yasuhiro ;
Thapa, Babu Ram ;
Wai, Chun-Tao ;
Yuen, Man-Fung .
HEPATOLOGY INTERNATIONAL, 2009, 3 (01) :269-282