Correlation of TLR1-10 expression in peripheral blood mononuclear cells with chronic hepatitis B and chronic hepatitis B-related liver failure

被引：50

作者：

Wang, Ke ^{[1
]}

Liu, Hongli ^{[1
]}

He, Yingli ^{[1
]}

Chen, Tianyan ^{[1
]}

Yang, Yuan ^{[1
]}

Niu, Yinghua ^{[1
]}

Chen, Hongmei ^{[1
]}

Chen, Yunru ^{[1
]}

Liu, Jinfeng ^{[1
]}

Ye, Feng ^{[1
]}

Lin, Shumei ^{[1
]}

Zhao, Yingren ^{[1
]}

机构：

[1] Xi An Jiao Tong Univ, Coll Med, Affiliated Hosp 1, Dept Infect Dis, Xian, Shaanxi Prov, Peoples R China

来源：

HUMAN IMMUNOLOGY | 2010年 / 71卷 / 10期

关键词：

Hepatitis B virus; Toll-like receptor; Chronic hepatitis B; Chronic hepatitis B-related liver failure; Peripheral blood mononuclear cells; Innate immunity; TOLL-LIKE RECEPTORS; VIRUS REPLICATION; OLIGODEOXYNUCLEOTIDE; DISEASE; INNATE;

D O I：

10.1016/j.humimm.2010.07.013

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Toll-like receptors (TLRs) promote host defenses against invading viruses and pathogenic bacteria through corresponding adapter molecules leading to the initiation of innate immune response. We investigated the expression of TLR1-10 in peripheral blood mononuclear cells (PBMCs) from patients with different clinical phases of chronic hepatitis B (CHB) infection and analyzed the correlation between TLRs and clinical profiles. Our results showed that expression of TLR3/5/7/9/10 and TLR2/4/6 mRNA was upregulated in active stage of CHB and CHB-related liver failure, respectively. Particularly we found that TLR9 mRNA expression is negatively correlated with serum alanine aminotransferase (ALT), Tbil, PTA, and positively correlated with hepatitis B virus (HBV) viral load in CHB patients. Our results indicate that innate immune responses are significantly higher in CHB active phase than that in CHB-related liver failure, suggesting TLRs may play a critical role in development of CHB and CHB-related liver failure, the mechanisms need further to be further explored. Crown copyright (C) 2010 Published by Elsevier Inc. on behalf of American Society for Histocompatibility and Immunogenetics. All rights reserved.

引用

页码：950 / 956

页数：7

共 27 条

[1]

Toll-like receptor signalling [J].