Toll-like receptor signaling inhibits hepatitis B virus replication in vivo

被引：374

作者：

Isogawa, M ^{[1
]}

Robek, MD ^{[1
]}

Furuichi, Y ^{[1
]}

Chisari, FV ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Mol & Expt Med, La Jolla, CA 92037 USA

来源：

JOURNAL OF VIROLOGY | 2005年 / 79卷 / 11期

关键词：

D O I：

10.1128/JVI.79.11.7269-7272.2005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Toll-like receptors (TLR) play a key role in innate immunity. To examine the ability of diverse TLRs to modulate hepatitis B virus (HBV) replication, HBV transgenic mice received a single intravenous injection of ligands specific for TLR2, TLR3, TLR4, TLR5, TLR7, and TLR9. All of the ligands except for TLR2 inhibited HBV replication in the liver noncytopathically within 24 It in a alpha/beta interferon-dependent manner. The ability of these TLR ligands to induce antiviral cytokines at the site of HBV replication suggests that TLR activation could represent a powerful and novel therapeutic strategy for the treatment of chronic HBV infection.

引用

页码：7269 / 7272

页数：4

共 32 条

[1] Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3 [J].

Alexopoulou, L ;

Holt, AC ;

Medzhitov, R ;

Flavell, RA .

NATURE, 2001, 413 (6857) :732-738

[2] Inhibition of hepatitis B virus replication during adenovirus and cytomegalovirus infections in transgenic mice [J].

Cavanaugh, VJ ;

Guidotti, LG ;

Chisari, FV .

JOURNAL OF VIROLOGY, 1998, 72 (04) :2630-2637

[3] Interleukin-12 inhibits hepatitis B virus replication in transgenic mice [J].

Cavanaugh, VJ ;

Guidotti, LG ;

Chisari, FV .

JOURNAL OF VIROLOGY, 1997, 71 (04) :3236-3243

[4] Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA [J].

Diebold, SS ;

Kaisho, T ;

Hemmi, H ;

Akira, S ;

Sousa, CRE .

SCIENCE, 2004, 303 (5663) :1529-1531

[5] Mice lacking myeloid differentiation factor 88 display profound defects in host resistance and immune responses to Mycobacterium avium infection not exhibited by Toll-like receptor 2 (TLR2)- and TLR4-deficient animals [J].

Feng, CG ;

Scanga, CA ;

Collazo-Custodio, CM ;

Cheever, AW ;

Hieny, S ;

Caspar, P ;

Sher, A .

JOURNAL OF IMMUNOLOGY, 2003, 171 (09) :4758-4764

[6]

Franco A, 1997, J IMMUNOL, V159, P2001

[7] HIGH-LEVEL HEPATITIS-B VIRUS-REPLICATION IN TRANSGENIC MICE [J].

GUIDOTTI, LG ;

MATZKE, B ;

SCHALLER, H ;

CHISARI, FV .

JOURNAL OF VIROLOGY, 1995, 69 (10) :6158-6169

[8] Noncytopathic clearance of lymphocytic choriomeningitis virus from the hepatocyte [J].

Guidotti, LG ;

Borrow, P ;

Brown, A ;

McClary, H ;

Koch, R ;

Chisari, FV .

JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (10) :1555-1564

[9] Intracellular inactivation of the hepatitis B virus by cytotoxic T lymphocytes [J].

Guidotti, LG ;

Ishikawa, T ;

Hobbs, MV ;

Matzke, B ;

Schreiber, R ;

Chisari, FV .

IMMUNITY, 1996, 4 (01) :25-36

[10] The poxvirus protein A52R targets toll-like receptor signaling complexes to suppress host defense [J].

Harte, MT ;

Haga, IR ;

Maloney, G ;

Gray, P ;

Reading, PC ;

Bartlett, NW ;

Smith, GL ;

Bowie, A ;

O'Neill, LAJ .

JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 197 (03) :343-351

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