抵抗素、Ⅱ型糖尿病和血管形成

被引:1
作者
王方圆 [1 ]
吴明媛 [1 ]
谢超 [2 ]
韩伟 [1 ]
机构
[1] 上海交通大学药学院再生医药学研究室
[2] 上海交通大学农业与生物学院上海市兽医生物技术重点实验室
关键词
抵抗素; 胰岛素抵抗; 糖原代谢; 血管生成; 心脏保护;
D O I
10.13241/j.cnki.pmb.2009.05.038
中图分类号
R587.1 [糖尿病];
学科分类号
摘要
抵抗素是近年来新发现的一个富含半胱氨酸的多肽,由于具有拮抗胰岛素的作用而得名。在啮齿类动物中,抵抗素主要由脂肪细胞特异性表达和分泌。目前对抵抗素的研究已获得了重要突破与进展,其三维结构也得到了证实。它不仅是联系肥胖症和Ⅱ型糖尿病的重要蛋白,而且具有多种生物学功能,如干扰肝细胞的糖原代谢、促进内皮细胞增殖迁移和血管生长、减少心梗面积等。本文主要介绍抵抗素的最新研究进展,以及抵抗素在Ⅱ型糖尿病和血管形成中的重要作用。
引用
收藏
页码:967 / 969
页数:3
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